Archive for October, 2010

Mesothelioma Clinical Trial-An overview of three important clinical trials

Mesothelioma Clinical Trial-An overview of three important clinical trials

Clinical trials are used to find out whether the treatment is safe for general use and whether it is actually effective against diseases. Participation in clinical trials is an important treatment option for many patients with mesothelioma as much of the currently used treatments offer little hope for a cure.

Mesothelioma is very resistant to treatment  and medical experts believe that there could be an epidemic of mesothelioma cases in years to come. Clinical trials (research studies with people) are designed to find new treatments and better ways to use current treatments, raising hope for victims of this devastating disease. These are three important ongoing clinical trials for mesothelioma treatment.

1-Phase III Vorinostat (SAHA) clinical trial for progressive or relapsed malignant pleural mesothelioma patients. This trial is studying the use of chemotherapy drug vorinostat to kill cancerous cells and stop their division, it is also believed that the drug can inhibit enzymes that are needed by the cancerous cells for growth and multiplication. These studies are currently in the third phase to understand its effects on epithelial, sarcomatous, and recurrent mesothelioma. Phase III Vorinostat (SAHA) trials for progressive or relapsed malignant pleural mesothelioma patients are currently underway at the Jonsson Comprehensive Cancer Center at UCLA and Warren Grant Magnuson Clinical Center – NCI Clinical Studies Support, Bethesda, Maryland.

2-Phase II AZD2171 clinical trial for patients with unresectable malignant mesothelioma Phase II AZD2171 for patients with unresectable malignant mesothelioma is investigating the use of chemotherapy drugs to inhibit enzymes that slow the growth and block the supply of blood into the cancerous cells. Cancer cells depend on the formation of new blood vessels to bring blood that will supply the nutrients that they need for growth, new drugs are being studied that will inhibit the development of these new blood vessels. This study hopes to result in the development of drugs that will be used to treat epithelial, sarcomatous, advanced, and recurrent malignant mesothelioma. These clinical trials are underway in Arizona, Georgia, Illinois, Indiana, Iowa, Kansas, Massachusetts, Michigan, Missouri, Montana, North Carolina, Ohio, South Carolina, Tennessee, Virginia, Washington, and Wyoming.

3-Phase II clinical trial on the use of Pemetrexed Disodium with Gemcitabine or Carboplatin in advanced malignant mesothelioma patients. The Phase II clinical trial on the use of Pemetrexed Disodium with Gemcitabine or Carboplatin in advanced malignant mesothelioma patients clinical is a study to study the effects of chemotherapy drugs pemetrexed disodium, gemcitabine, and carboplatin on advanced and recurrent malignant mesothelioma. This study is in phase II and is being conducted in several locations across the country including Delaware, Florida Illinois, Indiana, Iowa, Maryland, Michigan, New Jersey, New York, Ohio, Pennsylvania, South Dakota, and Wisconsin.

Mesothelioma victims should always endeavor to ask their oncologist about available clinical trials in their area.

Bello Kamorudeen. For more information on mesothelioma clinical trials go to http://www.mesotheliomacorner.blogspot.com


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Mesothelioma Law Firm with Experienced Asbestos lawyers-Mesothelioma attorneys for your asbestos mesothelioma lawsuits

Mesothelioma Law Firm with Experienced Asbestos lawyers-Mesothelioma attorneys for your asbestos mesothelioma lawsuits

Mesothelioma is a deadly disease caused most of the time by asbestos, a natural mineral used in industries.  This deadliest disease affects the lining of the various organs like lungs, heart, abdomen and other regions.  Mesothelioma may take several years to develop in a person who has been exposed to asbestos.

If you or someone you love have been diagnosed with Mesothelioma or asbestos related cancer, you may be entitled to millions of dollars in damages set aside by companies. – YOU HAVE RIGHTS. GET THE JUSTICE YOU DESERVE AND EASE YOUR FINANCIAL BURDEN

If you have been diagnosed with Mesothelioma, you have probably been exposed to asbestos before and you have the right to make a litigation to have a suitable compensation from the manufacturing company that let him/her to deal with Asbestos. The Mesothelioma settlement can reach millions of dollars for your asbestos lawsuits

To make good Mesothelioma litigation, then it is always best in these circumstances to talk to a good Mesothelioma asbestos lawyer who will help you in your right to make a claim for a suitable compensation which can reach millions of dollars.

The National Law Firm named MYMesoRights as the plaintiff’s hot list. This firm is considered as one of the top most law firms for mesothelioma case types. They give clients and their families the care and respect they deserve. They know that each case is unique, and every Mesothelioma victim is a person whose life has been destroyed by some irresponsible company or distributor of asbestos.

Our asbestos mesothelioma law firm has helped thousands of people recover over billion* in settlements to help ease the burden of this tragic disease. Contact us today and we’ll have someone working on your case in less than 24 hours.

Headquarters of MYMesoRights are in Pleasanton, California, but they serve the entire United States and have successfully represented clients in almost every state. Make a call to toll-free number 1- 800-916-0765 if you would like to consult with an experienced mesothelioma lawyer at no cost.

For more information on Mesothelioma attorneys visit: www.mymesorights.com

Dona Lawrence is a regional adviser for a company in CA. as, get advantaged by the services of this law firm, suggested this to all our USA citizens


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How to Choose the Best Mesothelioma Clinical Trial

How to Choose the Best Mesothelioma Clinical Trial

You can find out about good mesothelioma clinical trials in different ways. You can enter for clinical trials do so after hearing about them from your doctor. You can also actively look for clinical trials on the Internet or in other places, hoping to find more options for treatment. Some clinical trials are advertised directly to patients.

Information about mesothelioma cancer resources can be obtained from several resources. These resources can be divided into 2 main types: clinical trials lists and clinical trials matching services.

1- Clinical trial lists

These sources give you the names and descriptions of clinical trials of new treatments. If there is a study you are interested in, you will probably be able to find it in a list. The list will often include a description of the study, the criteria for patient eligibility, and a contact person. If you (or your health care providers) are willing and able to read through descriptions of all the studies listed for your cancer type, then a list may be all you need. Some organizations that provide lists can help you narrow the list a little, according to the kind of treatment you are looking for (chemotherapy, immunotherapy, radiation therapy, etc.) and the stage of your cancer.

2- Clinical trials matching services

Over the past few years, several organizations have developed computer-based systems to match patients with studies they may be eligible for. This service is often offered online.

Each may differ somewhat in how it works. Some of the services allow you to search for clinical trials without registering at the site. If you have to register, they usually assure you that your information will be kept confidential. Either way, you will probably have to enter certain details, such as the type of cancer, the stage of the disease, and any previous treatments you may have had. When given this information, these systems can find clinical trials for which you may be eligible, and save you the time and effort of reading descriptions of studies that are not relevant to you. Some groups also allow you to subscribe to mailing lists so that you are informed as new studies open up.

Although they are usually free to users, most clinical trial matching services get paid for listing studies or get a finder’s fee from those running the studies when someone enrolls. Because of this, there may be some differences in the way they rank the studies, or the order in which they present the studies to you.

Because different services work differently, be sure you understand how the service you are looking at operates. Ask the following questions. (Note that the answers do not necessarily mean that the service is not worth using.)
•Is there a fee for using the service?
•Do I have to register to use the service?
•Does the service keep my information confidential?
•Where does the service get its list of clinical trials?
•Does the service rank the studies in any particular order? Is this based on fees they get?
•Can I contact the service through the Internet or by telephone?

Examples of clinical trials matching services are:

1- The American Cancer Society Clinical Trials Matching Service:
The American Cancer Society helps patients find high quality care in clinical trials that best match their medical needs and personal preferences, while helping researchers study more effective treatments for future patients

The TrialCheck® database, developed and maintained by the Coalition of Cancer Cooperative Groups, is a comprehensive database that includes the Coalition, National Cancer Institute, and industry trials. To our knowledge, this is the most complete matching database of cancer clinical trials available.

The clinical trials information provided by the American Cancer Society is not biased in any way. It is updated every day, as is the contact information that allows patients to get in touch with the doctors and nurses at cancer centers running each of the studies.
You can access the TrialCheck at www.cancer.org (click on “Find a Clinical Trial”) or through a toll-free number, 1-800-303-5691.

2- The National Cancer Institute (NCI) sponsors most government-funded cancer clinical trials. The NCI has a list of active studies (those currently enrolling patients), as well as some privately funded studies. You can find the list on their Web site at www.cancer.gov/clinicaltrials or by calling 1-800-4-CANCER (1-800-422-6237). You can search the list by the type and stage of cancer, by the type of study (for example, treatment or prevention), or by zip code.

3- The National Institutes of Health (NIH) has an even larger database of clinical trials at www.clinicaltrials.gov, but not all of these are cancer studies.

4- EmergingMed provides a free and confidential matching and referral service for cancer patients looking for clinical trials at www.emergingmed.com, or you can call 1-877-601-8601.

5- CenterWatch (www.centerwatch.com) is a publishing and information services company that keeps a list of both industry-sponsored and government-funded clinical trials for cancer and other diseases.

6- Private companies, such as pharmaceutical or biotechnology firms, may list the studies they are sponsoring on their Web sites or offer toll-free numbers so you can call and ask about them. Some of these firms also offer matching systems for the studies they sponsor. This can be helpful if you are interested in research on a particular experimental treatment and know which company is developing it.

Bello kamorudeen.For more information on Mesothelioma treatment go to http://www.mesotheliomacorner.blogspot.com


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Scientists Conduct Clincial Trials of Peritoneal Mesothelioma Treatment

Scientists Conduct Clincial Trials of Peritoneal Mesothelioma Treatment

Researchers recently published the results of a study in the Journal of Clinical Oncology detailing a potentially new treatment for patients of abdominal mesothelioma that will likely improve the condition for patients.

The study found that when patients suffering from abdominal mesothelioma were given a combination of two drugs, Alimta (pemetrexed) and Gemzar (gemcitabine), their condition improved. The following are the results of the study:

* Response rate among patients was 15 percent.

* The control rate of the disease for patients while on the medication was 50 percent.

* The median time to disease progression was 10.4 months.

* The median survival time was 26.8 months.

* The mesothelioma study involved 20 patients suffering from the condition.

In addition to the two drugs, the patients received dexamethasone, folic acid and vitamin B12. The study was conducted by researchers involved in a multi-center U.S. trial. Researchers expect to continue studying the drugs?ffects on abdominal mesothelioma patients to determine if the treatment can be improved.

What is Abdominal Mesothelioma?

Abdominal mesothelioma is an extremely rare form of mesothelioma cancer. Commonly described as peritoneal mesothelioma, the cancer affects the abdominal lining, which is also known as the peritoneum. Within the abdominal cavity is the serous membrane, which is also known as the parietal peritoneum, and this membrane continues on to the visceral peritoneum that lines the organs. With abdominal mesothelioma, the visceral and parietal peritoneum linings are affected with the development of cancerous cells.

Most often, abdominal cancer occurs when an individual first develops pleural mesothelioma, which is when the lining of the lung develops cancerous cells after inhalation of asbestos. Pleural mesothelioma can then spread to the peritoneal cavity and cause peritoneal mesothelioma, which accounts for less than one-third of all mesothelioma diagnoses.

How is Peritoneal Mesothelioma Contracted?

Abdominal, or peritoneal, mesothelioma is caused through the inhalation of asbestos fibers or asbestos dust. Asbestos is a material that is derived from vermiculite, a mineral that was mined heavily in the United States and around the world in the 20th century. Asbestos was most commonly used as an insulation within the construction industry because it was flame resistant and was developed at inexpensive prices.

An array of mild to severe mesothelioma symptoms exist, including:

* shortness of breath.

* inability to breath.

* fatigue.

* wheezing or severe cough.

However, many of these symptoms are generalized to overall cases of mesothelioma. Specific symptoms exist for those diagnosed with peritoneal mesothelioma. These symptoms are as follows:

* weight loss.

* abdominal swelling, which can be caused by ascites or the buildup of fluid in the abdominal cavity.

* bowel obstruction.

* fever.

* anemia.

* blood clotting.

* trouble swallowing.

* swelling of neck and face.

Abdominal Mesothelioma Treatment

Abdominal mesothelioma treatments commonly consist of surgical procedures to remove the infected cancerous areas. Often, the main surgery involved with peritoneal mesothelioma is known as cytoreductive surgery. While many individuals will receive specific treatments based on their case, the surgery usually is coupled with a chemotherapy treatment — this treatment is often called the perioperative intraperitoneal chemotherapy and has been shown to slightly improve the median survival rate.

Obtaining Peritoneal Mesothelioma Legal Help

Individuals who have been diagnosed with peritoneal mesothelioma or any similar form of mesothelioma cancer are advised to locate an experienced mesothelioma attorney. Individuals who have been exposed to mesothelioma should contact a medical professional immediately because of the dangers that exist to even limited exposure to asbestos. These individuals may be able to receive monetary compensation for the extremely costly medical bills associated with abdominal mesothelioma.

It is especially important for an individual to seek legal counsel for their mesothelioma lawsuit if they were an employee within the metal, mining, maritime, construction and welding industries.

For information on the various forms of mesothelioma, visit http://mesothelioma.legalview.com/. Individuals can also visit http://www.LegalView.com to learn about other potentially damaging legal dilemmas adversely affecting Americans, such as the Zimmer Durom cup side effects and the Cipro warnings.


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