Archive for December, 2010

Asbestos Exposure Results in Deadly Cancer

Asbestos Exposure Results in Deadly Cancer

Malignant mesothelioma is a rare cancer of the lining of the lung (pleural mesothelioma) or the lining of the abdomen (peritoneal mesothelioma). The only known cause of mesothelioma in the U.S. is exposure to asbestos. Mesothelioma has a long latency period, the time between first exposure to asbestos and the diagnosis of the disease. In rare cases the latency period has been as short as 10 to 15 years after the first exposure to asbestos; however, generally mesothelioma occurs between 20 and 40 or more years after an individual’s first exposure. Diagnosing mesothelioma is often difficult, because the symptoms are similar to those of a number of other conditions.


Benign mesothelioma is a non-cancerous tumor of the pleura (lining of the lung and chest cavity). Nonmalignant mesothelioma is usually a localized tumor that affects men more frequently than women. The tumor may grow to a large size and compress the lung, which then causes the following symptoms: chronic cough, shortness of breath, chest pain, weight loss and cachexia, abdominal swelling and pain due to ascites (a buildup of fluid in the abdominal cavity).


Other symptoms of peritoneal mesothelioma may include bowel obstruction, blood clotting abnormalities, anemia, and fever. If the cancer has spread beyond the mesothelium to other parts of the body, symptoms may include pain, trouble swallowing, or swelling of the neck or face. These symptoms may be caused by mesothelioma or by other, less serious conditions.


Approximately half of mesothelioma patients are asymptomatic (show no symptoms of disease). During a physical examination, a health care provider may notice a clubbed appearance of the fingers in a patient, which is an indication of the exposure/disease.The health care professional may run tests that identify mesothelioma. These tests include a chest x-ray, CT scan of the chest and/or and open lung biopsy.


There is no universally accepted protocol for screening people who have been exposed to asbestos. However some research indicates that serum osteopontin levels might be useful in screening asbestos-exposed people for mesothelioma. The level of soluble mesothelin-related protein is elevated in the serum of about 75% of patients at diagnosis, and it has been suggested that assessing soluble mesothelin-related protein levels may be useful for screening.


Surgery is usually generally necessary for a solitary tumor (if found); however, according to current statistics, the outcome of the surgery is expected to be good with prompt treatment. One of the most common complications though is pleural effusion (fluid escaping into the membranes around the lungs), which can be very serious.


Most people who develop mesothelioma have worked on jobs where they inhaled asbestos particles, or have been exposed to asbestos dust and fiber in other ways, such as by washing the clothes of a family member who worked with asbestos, or by home renovation using asbestos cement products.

Visitors to LegalView.com will be able to browse a collection of resources including help to find a brain injury lawyer, an auto accident law firm, construction accident attorney and more. You can also get help to find a mesothelioma attorney at http://mesothelioma.legalview.com/.


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How Are People Exposed to Asbestos?

How Are People Exposed to Asbestos? www.mesorc.com People who work with asbestos-containing materials on a regular basis account for the highest levels of asbestos exposure. Certain jobs and work environments, like mining, factory work, ship building, and construction work, are more likely to result in asbestos exposure than others. Studies have even shown that the family members of asbestos workers have suffered asbestos exposure from fibers brought home on the workers’ clothing. In fact, second hand asbestos exposure is increasingly being recognized as a direct cause of mesothelioma, lung cancer and other types of serious asbestos-related illnesses. Asbestos exposure can also occur in the home from building materials wearing down and releasing fibers into the air. It can occur among people who live near an asbestos mine. Drinking water may even contain asbestos fibers. This happens when: -Fibers erode from natural deposits or piles of waste asbestos and enter the water -Fibers enter water from asbestos-containing cement pipes used to carry drinking water -Water is filtered through asbestos-containing filters. The Environmental Protection Agency (EPA) requires water suppliers to test water samples regularly. Suppliers must notify the public via newspapers, radio, TV, and other means if levels are higher than allowed. The biggest risk factor for developing the deadly cancer mesothelioma is asbestos exposure. The risk is directly related to how much exposure a person had

Asbestos lung mesothelioma – Mesothelioma and the Asbestos Time Bomb

Asbestos lung mesothelioma – Mesothelioma and the Asbestos Time Bomb

The one-time friend turned killer as soon as it is an essential but unseen part of everyday life for many centuries, is now a formidable opponent. There is asbestos (from the Greek word for “unquenchable”) and is the reason for the thousands of claims that global employers mesothelioma, producer of asbestos products. Many asbestos workers, and those exposed to asbestos unwitingly are against lawyers whogiven a diagnosis of mesothelioma for which there is no cure, maybe just a bit ‘of temporary relief, until the inevitable painful death a few months or years after diagnosis.

Mesothelioma is a time bomb, because it may be that a day’s less exposure to asbestos is mesothelioma produce enough, 30-40 years later when I first noticed the symptoms of mesothelioma. Although the majority of mesothelioma victims are men, mainly becauseworked in these areas, sometimes their wives and families are also innocent of this disease suffer from inhalation of asbestos dust swirl the hair from their husbands / fathers clothes or the end of the workday.

http://www.asbestoslungmesotheliomaaa.goodarticlesite.com/mesothelioma-and-the-asbestos-time-bomb/

If the fault lies with manufacturers and employers (if they knew of the dangers) or staff (everyone diligently use respirator equipment and protective clothing when it was delivered?), Is something for the mesothelioma lawyersInsurance companies and courts to thrash out.

http://www.asbestoslungmesotheliomaaa.goodarticlesite.com/mesothelioma-and-the-asbestos-time-bomb/

Meanwhile, asbestosis and mesothelioma are victims of a painful and inexorable death, even before their cases to court or settlement has been reached. Since there is no cure for mesothelioma or asbestosis, all that can be done to alleviate the suffering and misery to make it as pleasant as possible, before death finally brings Mercyful. Although many governments have introduced, albeit belatedly, anti-asbestosLegislation are concerned that in some cases, the period for seeking compensation is unrealistically short, given
the long (30-40 years) before symptoms of mesothelioma are first noticed. Many victims die before a verdict of the court or even before arriving in court. In contrast to its Greek derivation, Mesothelioma and asbestosis victims are not erasable.

READ MORE http://www.asbestoslungmesotheliomaaa.goodarticlesite.com/mesothelioma-and-the-asbestos-time-bomb/

Treatments of Mesothelioma Cancer

Treatments of Mesothelioma Cancer

There are treatments for all patients with malignant Mesothelioma. However, the treatment option that is chosen for a particular patient depends on a number of factors such as the location of the cancer, the stage of the disease, patient’s age and general health, the extent of the damage, etc. treatment is generally of three kinds,

1. Surgery in which case the cancerous portion is removed from the body.
2. Radiation therapy (using x-rays or other high-energy rays to kill cancer cells).
3. Chemotherapy (using drugs to fight the cancer).

Surgery
Surgery is the physical way of treating Mesothelioma in which the cancerous cells are physically removed. Surgery is a common way to treat malignant Mesothelioma. The doctor may remove part of the lining of the chest or abdomen and some of the tissue around it. Sometimes, if the cancer has spread widely, a lung can be totally removed in a surgical procedure called a pneumonectomy. Along with the lung, part of the diaphragm, is also sometimes removed, diaphragm is the muscle below the lungs that helps with breathing. This will temporarily solve the problem of difficulty in breathing.

Radiation Therapy
In radiation therapy high-energy x-rays are used to kill cancer cells and shrink tumors. There are two kinds of radiation therapy, external radiation therapy and internal radiation therapy. When the radiation comes from a machine outside the body it is called external radiation therapy. When materials that produce radiation, are put inside the body through thin plastic tubes in the area where the cancer cells are found, it is called internal radiation therapy.

To relieve symptoms and control pain, the doctor may use a needle or a thin tube to drain fluid that has built up in the chest or abdomen. The procedure for removing fluid from the chest is called thoracocentesis. Removal of fluid from the abdomen is called paracentesis. Drugs may be given through a tube in the chest to prevent more fluid from accumulating. Radiation therapy and surgery may also be helpful in relieving symptoms.

Chemotherapy
Chemotherapy uses drugs to kill cancer cells. Chemotherapy may be taken by pill, or it may be put into the body by a needle in the vein or muscle. Chemotherapy is called a systemic treatment because the drug enters the bloodstream, travels through the body, and can kill cancer cells throughout the body. In Mesothelioma, chemotherapy may be put directly into the chest (intrapleural chemotherapy).

Treatment options for people with Mesothelioma have improved significantly. This is more so in cases where the diagnosis has been early and treatment has been aggressive. Many people are treated with a combination of the above-discussed therapies and this is known as multimodal therapy. Mesothelioma is a fatal disease and so far no cure has been found for the disease. However, treatments can reduce pain and improve lung function. Easily administered pain killers are now used to control pain.

Rob Mellors helps people find out about mesothelioma and mesothelioma treatment


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Active Symptom Control For Mesothelioma Studied For Chemotherapy Treatment

Active Symptom Control For Mesothelioma Studied For Chemotherapy Treatment

Active control of the symptoms of mesothelioma in chemotherapy studied

According to a recent issue of the British medical journal, The Lancet, researchers have been studying the effect of chemotherapy in mesothelioma. Because chemotherapy is not considered a successful treatment for mesothelioma cancer, but a treatment for mesothelioma signs and symptoms of medical professionals to continue the discussion of the usefulness of the procedure in controlling symptoms.

The researchers studied 409 patients of all who suffer from malignant pleural mesothelioma in different parts of the world. Patients were randomly assigned a treatment of symptoms or treatment that included an active control treatment with two chemotherapy drugs. According to the study, “the active symptom control treatments include steroids, bronchodilators, analgesic drugs and palliative radiotherapy.”

After the study, patients in both treatment options were compared and, according to investigators, “the addition of chemotherapy to control the symptoms showed a non significant benefit or advances in survival or quality of life” among the victims of mesothelioma.

What is mesothelioma, chemotherapy?

Mesothelioma is a malignant disease in which cancer cells develop in a thin layer of tissue that is the thoracic cavity that covers the lungs, which is also known as the pleura or peritoneum, the tissue lining the abdomen and Most of the bodies, according to the National Cancer Institute (NCI).

According to the American Cancer Society (ACS), chemotherapy is a treatment method that uses chemicals commonly administered through a catheter, pill, injection, or the port, which is usually a round disk of metal or plastic , which is when cancer cells begin to develop abnormal and divide uncontrollably fast. Chemotherapy is given for a variety of reasons, but is based on certain factors such as stage of cancer, a patient’s health and age of a patient. For patients with mesothelioma, chemotherapy is not a method of cure, but is administered to patients with mesothelioma for several reasons including:

* Halting the growth and spread of cancer, to control cancer

* Minimize or reduce tumors – this method is also known as neoadjuvant chemotherapy

* The palliative chemotherapy on pain and other symptoms have to be reduced

* The destruction of microscopic disease that remains after a surgical procedure, also known as adjuvant chemotherapy

Chemotherapy is given as a catheter into a large vein in the body or a catheter is attached as a port that is placed on the chest under the skin for a period of time.

Living with Mesothelioma

Unfortunately, victims of mesothelioma receive further setbacks in his life-threatening condition, as currently there is no successful treatment for cancer death. However, a person has the opportunity to participate in a series of clinical trials of the treatment groups, as well as the opportunity to develop mesothelioma a demand for monetary compensation as a means of payment for the condition, which is often associated with the very expensive medical bills.

For more info please visit our site @ www.chemotherapy2k.com


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More Mesothelioma Chemotherapy Articles

Pulmonary Toxicity and Malignant Mesotheliomas

Pulmonary Toxicity and Malignant Mesotheliomas

Another interesting study is called, “Potential Role of Histone Deacetylase Inhibitors in Mesothelioma: Clinical Experience with Suberoylanilide Hydroxamic Acid
Clinical Lung Cancer” – Chest Surg Clin N Am. 1994 Feb;4(1):113-26 – Allen KB, Faber LP, Warren WH.  Here is an excerpt: “Abstract – Diffuse malignant pleural mesothelioma is an uncommon, uniformly fatal malignancy. Controversy continues to surround the optimal surgical procedure, both extrapleural pneumonectomy or pleurectomy, which should be utilized in conjunction with post-operative chemotherapy and/or radiotherapy. This retrospective study reviews a single institution’s experience with extrapleural pneumonectomy and pleurectomy in the multimodality treatment of diffuse malignant pleural mesothelioma.

Another interesting study is called, “Phase II trial of mitomycin in malignant mesothelioma.” By Bajorin, D, Kelsen, D, Mintzer, DM – CANCER TREAT. REP. Vol. 71, no. 9, pp. 857-858. 1987.  Here is an excerpt: “Malignant mesothelioma is a highly lethal neoplasm. Recent data noted in vivo antineoplastic effects of a combination of mitomycin and cisplatin (DDP) greater than either agent alone in human tumor xenograft mesothelioma. While DDP singly has some efficacy, mitomycin has not been systematically evaluated in this disease. A phase II trial was therefore conducted to determine the activity of mitomycin in malignant mesothelioma. Pulmonary toxicity was substantial. Two responding patients developed dyspnea and hypoxemia occurring at cumulative doses of 40 and 50 mg/m super(2), respectively. One patient had a transbronchial biopsy consistent with drug-induced pulmonary fibrosis and never achieved resolution of hypoxemia with corticosteroid therapy prior to death from progressive mesothelioma. The second patient responded to corticosteroid therapy with resolution of dyspnea and hypoxemia but relapsed after discontinuing mitomycin.”

Another interesting study is called, “Immunohistological staining of reactive mesothelium, mesothelioma, and lung carcinoma with a panel of monoclonal antibodies.” – J Clin Pathol 1987;40:19-25 by A K Ghosh, K C Gatter, M S Dunnill, D Y Mason.  Here is an excerpt: “Abstract – A panel of seven monoclonal antiepithelial antibodies of different specificities, including anticytokeratin, human milk fat globule membrane, C, and carcinoembryonic antigen (CEA) were used with the alkaline phosphatase-antialkaline phosphatase (APAAP) immunostaining technique to determine their value in the differentiation between benign and malignant mesothelial cells and lung carcinoma in histological preparations. The anticytokeratin antibody reacted strongly with all cases of reactive mesothelium, mesothelioma, and lung carcinoma. Antibodies to human milk fat globule membrane and the Ca antigen stained mesothelioma and carcinoma and 43% of cases of reactive mesothelium. Staining for carcinoembryonic antigen was not detected in reactive mesothelium or mesothelioma, but was present in most of the lung carcinomas. CEA seemed to be the single most useful marker in distinguishing carcinoma from mesothelioma in that a positive reaction for CEA would indicate carcinoma rather than mesothelioma.”

Another interesting study is called, “Podoplanin as a marker for Mesothelioma” by Noriko Kimura, Itaru Kimura – Pathology International – Volume 55, Issue 2, pages 83–86, February 2005.  Here is an excerpt: “Podoplanin is a specific marker for lymph vessel endothelial cells. It was noted that podoplanin is expressed in reactive mesothelial cells. The utility of podoplanin for the histological diagnosis of tumors was then investigated, especially for mesothelioma. Immunohistochemical study of podoplanin was carried out in five malignant mesotheliomas and 118 other tumors including 93 adenocarcinomas, four squamous cell carcinomas, six gastrointestinal stromal tumors and five endocrine tumors. Immunoreactivity for podoplanin was demonstrated on the cell membrane of tumor cells for all mesotheliomas. All other tumors were negative for podoplanin. Among the many antibodies used for differential diagnosis of malignant mesothelioma, podoplanin has the potential to be an excellent tumor marker in both specificity and sensitivity. The utility of podoplanin as a marker for mesothelioma will be confirmed by further studies.”

We all owe a debt of gratitude to these fine researchers.  If you found any of these excerpts interesting, please read the studies in their entirety.

Monty Wrobleski is the author of this article.  For more information please click on the following links

Depuy Hip Recall Attorney

Depuy Hip Recall Lawyer

Malignant Mesothelioma

 

 


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