Archive for the ‘Mesothelioma Deaths’ Category
Can You Survive A Mesothelioma Diagnosis?
November 28th, 2010 | 
Author: Can You Survive A Mesothelioma Diagnosis?
Mesothelioma is a form of cancer that is often associated with exposure to toxic asbestos products or materials. Being diagnosed with this cancer is seriously bad news as the median survival period for patients is roughly a year. Does that mean that you can’t survive Mesothelioma? Not at all.
Cancer is what is known as a growth disease. It consists of mutated cells that spread through the immediate area and eventually much of your body. Mesothelioma is a very unique form of cancer because it can take up to 50 years after exposure to asbestos to manifest. The cancer grows slowly, but is extremely hard to diagnose. The problem is the growth tends to occur in the mesothelium, which is a lining around the chest and abdomen as well as the organs therein. Most symptoms are confused with other diagnosis and the disease goes untreated until it is usually at a very late stage.
Any discussion about Mesothelioma comes with a rather unstated morbidity. The cancer is usually deadly, but that doesn’t mean there are not people who have survived it or that you could. As usual, the key is to try to discover it as early as possible. Problems breathing can be a tell tale sign and should be investigated early. Regardless, there are people who have survived the cancer. Let’s take a look at one.
Steven Gould was a famous historian and paleontologist at Harvard. In 1982, he was diagnosed with Mesothelioma at the age of 40. Located in his abdomen, he sought out aggressive treatment. Within two years, he was declared cancer free. He lived another 20 years until 2002. A very unlucky sort, he died at the age of 60 from Metatastic Adenocarcinoma of the lung. Despite its location, the cancer is glandular in nature and not related to Mesothelioma. Still, the good professor beat Mesothelioma.
Is it likely that you’ll beat this cancer if diagnosed with it? The statistics say no, but I’ve always hated statistics. Never give up. Pursue aggressive therapy and consider joining up with various trials that are focused on experimental treatments for Mesothelioma. The National Cancer Institute keeps a running list of such trials. Just think…if Gould had given up, he would have missed another 20 years of life.
Thomas Ajava is with AtlantaMesotheliomaInjuries.com – where you can learn more about Atlanta Mesothelioma injuries caused by asbestos exposure in the area.
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California considers renaming the state rock
California considers renaming the state rock
SACRAMENTO, California – California may well possibly rename their think rock (currently the serpentine) simply because it consists of the mineral asbestos which is identified to cause hazardous well being issues to individuals exposed to it.
When serpentine was 1st named the point out rock in 1965, asbestos was generally employed in construction due to its durability and thermal properties. Nonetheless, a long time later it came to be recognized that asbestos contributes to numerous detrimental medical conditions, such as the fatal mesothelioma cancer.
Asbestos is no longer mined in the United States due to the difficulties it can result in. Since of this, California lawmakers do not consider it’s proper to let the rock remain the point out icon.
Point out Senator, Gloria Romero who proposed the modify of express rock commented on the circumstance. “We know that California has the highest rates of mesothelioma deaths in the nation and we don’t feel it’s proper to be celebrating as the express rock anything which contains asbestos.”
Not everybody shares her sentiments nonetheless. Geologists as nicely as other business affiliates are protesting the bill, saying that the rock has been a symbol of the express for years and is being unfairly stigmatized. They argue that not all serpentine rocks consist of asbestos and the ones that do, most frequently consist of chrysotile, a lesser hazardous type.
When serpentine was very first staying utilized, miners would crush the rock to release the asbestos minerals inside it. Back then, lawmakers held a diverse point of view on asbestos and named serpentine the think rock in hopes that it would expand the asbestos sector which was generating millions of dollars each and every year.
As the debate goes on, the problem more than whether one particular form of asbestos getting a lot more hazardous than one more continues. Some. Like the Environmental Safety Agency, argue that asbestos that occurs normally in the ground and which remains undisturbed will not result in any health risks. Although the World Well being Organization contends that all forms of the mineral pose difficulties for people subjected to it.
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Workers And Their Families Exposed To Hazardous Asbestos Dust And Mesothelioma
Workers And Their Families Exposed To Hazardous Asbestos Dust And Mesothelioma
One group of people that have been particularly impacted by asbestos exposure is shipyward workers and their families. Asbestos was so prevalent in the construction of ships because of its fire retardant qualities and durability. During a ships construction, the workers would typically handle asbestos insulation products and consequently inhale large amounts of toxic dust. Unfortunately, many of these workers have died because of this asbestos exposure.
One thing we can all do is try to raise public awareness about asbestos exposure and the link to lung cancer and mesothelioma. One good study is called, “Asbestos exposure: factors associated with excess cancer and respiratory disease mortality.” By Henderson VL, and Enterline PE. Ann N Y Acad Sci. 1979; 330:117-26. Here is an excerpt:
“A cohort of 1075 men who completed their working lifetimes with an asbestos company, worked at a facility in the United States, and retired with a company pension during the period 1941–67 was updated for deaths through 1973. The average length of employment was 25 years, and all had been exposed to asbestos dust. Respiratory cancer and pneumoconiosis-pulmonary fibrosis mortalities were examined in relation to cumulative dust exposure and to other factors after taking into account cumulative dust exposure. Men who worked in the production of asbestos cement pipe exhibited a higher risk of respiratory cancer, as did men with some crocidolite asbestos exposure. Because these two groups overlap, we could not be certain that crocidolite asbestos was responsible for the increased risk. Men working in general plant maintenance displayed a striking lack of deaths due to pneumoconiosis-pulmonary fibrosis, as compared with production workers and with maintenance personnel assigned to specific departments. Five mesothelioma deaths were observed at age 65 and over. Three of these deaths occurred during the period 1970–3.”
Another good study worth looking at is called, “Asbestos-related pleural disease and asbestosis: a comparison of CT and chest radiography” by AC Friedman, SB Fiel, MS Fisher, PD Radecki, AS Lev-Toaff, and and DF Caroline – Department of Diagnostic Imaging, Temple University Hospital, Philadelphia, PA 19140. Here is an excerpt:
“High-resolution CT (HRCT) has the ability to demonstrate both asbestos-related pleural disease and parenchymal abnormalities consistent with asbestosis. The role of CT in the diagnosis of asbestosis can be defined by comparing it with radiography. We evaluated 60 men who had a history of occupational exposure to asbestos and whose outside chest radiographs were considered abnormal. Chest radiographs (inside films) and HRCT were performed in all patients at our institution and were interpreted independently by experienced radiologists. Outside film results were compiled from the submitted reports. The final conclusion regarding the interpretation of the radiologic examinations was determined by consensus when disagreements existed. Positive predictive values (the likelihood that a positive report is correct) for pleural disease were: outside films 56%, inside films 79%, HRCT 100%. The positive predictive values for parenchymal disease were: outside films 51%, inside films 83%, HRCT 100%. The addition of HRCT to chest radiography is most useful in eliminating false-positive diagnoses of asbestos-related pleural disease caused by subpleural fat and false-positive diagnoses of parenchymal asbestosis in patients with extensive plaques or emphysema obscuring lung detail. The interpretation of chest radiographs in patients exposed to asbestos is often extremely difficult and subjective, and we recommend that positive findings (except calcified plaques) be confirmed with HRCT.”
This article should not be construed as medical advice. Its purpose is to raise awareness. If you found either of these excerpts interesting, please read the studies in their entirety.
Monty Wrobleski is the author of this article on asbestos exposure lawsuit, asbestos attorney, and mesothelioma attorneys
There is a Cancer Epidemic Related to Asbestos Exposure
There is a Cancer Epidemic Related to Asbestos Exposure
There is a Cancer Epidemic Related to Asbestos Exposure
Asbestos exposure is responsible for the death of millions of people worldwide and the debate on how to handle this crisis is still ongoing. There are a myriad of political and economic obstacles surrounding the issue, and some are uncomfortable subjects to discuss.
One interesting article to start your research is called, “The asbestos cancer epidemic.” By Joseph LaDou – Division of Occupational and Environmental Medicine, University of California-San Francisco School of Medicine, – Environ Health Perspect. 2004 March; 112(3): 285–. Here is an excerpt: “The asbestos cancer epidemic may take as many as 10 million lives before asbestos is banned worldwide and exposures are brought to an end. In many developed countries, in the most affected age groups, mesothelioma may account for 1% of all deaths. In addition to mesotheliomas, 5-7% of all lung cancers can be attributed to occupational exposures to asbestos. The asbestos cancer epidemic would have been largely preventable if the World Health Organization (WHO) and the International Labor Organization (ILO) had responded early and responsibly.
The WHO was late in recognizing the epidemic and failed to act decisively after it was well under way. The WHO and the ILO continue to fail to address the problem of asbestos mining, manufacturing, and use and world trade of a known human carcinogen. Part of the problem is that the WHO and the ILO have allowed organizations such as the International Commission on Occupational Health (ICOH) and other asbestos industry advocates to manipulate them and to distort scientific evidence. The global asbestos cancer epidemic is a story of monumental failure to protect the public health.”
A second study worth examining is called, “Cancer in asbestos-exposed occupational cohorts: a meta-analysis” Cancer Causes and Control – Volume 10, Number 5 / August, 1999 – by Michael Goodman, Robert W. Morgan, Rose Ray, Curtis D. Malloy and Ke Zhao. Here is an excerpt: “Abstract Objective: To examine existing asbestos-exposed occupational cohorts and apply a meta-analytic technique to determine the magnitude of association between exposure and lung cancer and to investigate other cancer sites that may be related to such an exposure. Methods: We summarized the data from 69 asbestos-exposed occupational cohorts reporting on cancer morbidity and mortality. Data were extracted regarding numbers of deaths for each cancer, numbers of mesotheliomas, occupations and latency for respiratory, gastrointestinal, urinary and lymphohematopoietic cancers. For each cancer, we calculated a meta-SMR and examined heterogeneity of results using a chi-square test and by calculating a Z-statistic for each study. To examine the dose–response effect, we divided the studies into tertiles according to the percentage of mesothelioma deaths that served as a proxy estimation of asbestos exposure.
Results: Lung cancer data demonstrated meta-SMRs of 163 and 148 with and without latency, respectively, with significant heterogeneity of results even after stratification according to occupational groups. Stratification of lung cancer studies according to percentage of mesothelioma deaths showed a dose–response effect. Z-scores ranged from – 12.21 to + 29.49. Analysis for laryngeal cancer yielded meta-SMRs of 157 and 133 with and without latency, respectively, demonstrating homogeneous results across studies but accompanied by no evidence of a dose–response effect. Data for gastrointestinal cancers showed no evidence of a significant association and no dose–response effect. Kidney cancer demonstrated statistically non-significant meta-SMRs of 120 (95% CI 88–160) and 111 (95% CI 94–131) with and without latency respectively.
Conclusions: This meta-analysis demonstrates a wide variability of the association between occupational asbestos and lung cancer. There was a suggestion of an association between asbestos and laryngeal carcinoma and no clear association with other cancers.”
A third study is called, “Asbestos and renal adenocarcinoma: A case-control study” by Malcolm Maclure – Environmental Research Volume 42, Issue 2, April 1987, Pages 353. Here is an excerpt: “A case-control study of renal adenocarcinoma has corroborated the hypothesis that asbestos is a cause of the disease. The odds of having been moderately or heavily exposed to asbestos 30 years before diagnosis were 45:473 among cases, whereas the comparable odds among controls were 26:492. A matched-pair analysis yielded an exposure odds ratio of 1.8 with 95% confidence limits of 1.1 and 3.1. After controlling for potential confounders and selection factors by means of logistic regression, the incidence rate ratio was estimated to be 1.6, with a one-sided 95% confidence limit of 1.0.”
If you found any of these excerpts interesting, please read the studies in their entirety. We all owe a great deal of gratitude to these researchers.
Village ravaged by cancer in Turkey’s Cappadocia
Village ravaged by cancer in Turkey’s Cappadocia
(11-04) 08:19 PDT TUZKOY, Turkey (AP) — The caves, rock houses and fantastical stone formations in Turkey’s Cappadocia draw tourists from around the world. Nestled among the natural wonders, however, lies a village…
Read more on San Francisco Chronicle
Village ravaged by cancer in Turkey’s Cappadocia
Three villages in Turkey’s popular Cappadocia region are being ravaged by a rare cancer known as mesothelioma, which can be caused by a mineral that’s found in abundance in the area.
Read more on CTV.ca
Village ravaged by cancer in Turkey’s Cappadocia
The caves, rock houses and fantastical stone formations in Turkey’s Cappadocia draw tourists from around the world. Nestled among the natural wonders, however, lies a village where the earth is believed to deliver death…
Read more on Channel 8 San Diego
Inhibited Cell Growth and Asbestos Concentrations
Inhibited Cell Growth and Asbestos Concentrations
Inhibited Cell Growth and Asbestos Concentrations
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Inhibited Cell Growth and Asbestos Concentrations
Posted: Sep 12, 2010 |Comments: 0
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Inhibited Cell Growth and Asbestos Concentrations
By: Montwrobleski77
About the Author
Monty Wrobleski is the author of this article, for more information please visit the following links
(ArticlesBase SC #3251615)
Article Source: http://www.articlesbase.com/ – Inhibited Cell Growth and Asbestos Concentrations
Mesothelioma deaths among workers is a sad part of this country’s history. However, there is some important research being done regarding asbestos and its complications.
One interesting study is called, “Asbestos-induced sister chromatid exchanges in cultured Chinese hamster ovarian fibroblast cells.” By Livingston GK, Rom WN, Morris MV. – J Environ Pathol Toxicol. 1980 Sep;4(2-3):373-82. Here is an excerpt: “Abstract – Asbestos fibers were tested for possible mutagenic activity using the Fluorescent Plus Giemsa (FPG) sister chromatid exchange (SCE) technique. Amosite, crocidolite, and chrysotile fibers were added to cell cultures at final concentrations of 10 and 100 micrograms/ml. Chrysotile completely inhibited cell growth at both concentrations; cells exposed to amosite and crocidolite proliferated but only at the lower concentration. Crocidolite significantly elevated the SCE rate and larger (greater than 5 mu) chromosomes were most sensitive. Amosite appeared to have a lesser effect on SCE frequency. Asbestos fibers are capable of disturbing cellular processes associated with chromosomal stability and effects vary with the asbestos type.”
Another interesting study is called, “Mesothelioma among employees with likely contact with in-place asbestos-containing building materials.” By Anderson HA, Hanrahan LP, Schirmer J, Higgins D, Sarow P. – Ann N Y Acad Sci. 1991 Dec 31. Here is an excerpt: “Abstract – The occurrence of mesothelioma is a sentinel event in occupational and environmental disease. A mesothelioma surveillance system was established utilizing existing computerized Wisconsin vital statistics data maintained since 1959 and a Cancer Reporting System (CRS) established in 1978. Review of the death certificate listing of usual occupation and industry from 487 mesothelioma deaths in Wisconsin from 1959 to 1989 led to the investigation of 41 persons with likely exposure to inplace asbestos-containing building materials (ACBM): 12 school teachers, 10 school maintenance employees, 7 public building maintenance workers, 5 private building maintenance workers, and 7 commercial and factory workers performing maintenance activities. For 10 (34%) of the 29 maintenance workers the only source of asbestos exposure identified was their maintenance work. For five (17%) histories indicated some prior employment in occupations and industries with probable asbestos exposures. Opportunities for indirect occupational exposure were identified for ten who had been employed in the residential construction industry. One maintenance worker was exposed to asbestos in the household and another had neighborhood exposure. For 9 (75%) of the school teachers, the only identifiable potential source of asbestos exposure was derived from in-place ACBM in schools. One teacher had spent a season in the merchant marine aboard an iron ore-hauling ship and 2 had worked in the residential construction industry. Two of the teachers were sisters, and in two instances, two teachers had taught in the same school facility. We conclude that individuals occupationally exposed to in-place ACBM are at risk for the subsequent development of mesothelioma.”
Another interesting study is called, “Predictions of mortality from pleural mesothelioma in Italy: A model based on asbestos consumption figures supports results from age-period-cohort models” – International Journal of Cancer – Volume 115, Issue 1, pages 142–147, 20 May 2005. Here is an excerpt: “Abstract – Italy was the second main asbestos producer in Europe, after the Soviet Union, until the end of the 1980s, and raw asbestos was imported on a large scale until 1992. The Italian pattern of asbestos consumption lags on average about 10 years behind the United States, Australia, the United Kingdom and the Nordic countries. Measures to reduce exposure were introduced in the mid-1970s in some workplaces. In 1986, limitations were imposed on the use of crocidolite and in 1992 asbestos was definitively banned. We have used primary pleural cancer mortality figures (1970–1999) to predict mortality from mesothelioma among Italian men in the next 30 years by age-cohort-period models and by a model based on asbestos consumption figures. The pleural cancer/mesothelioma ratio and mesothelioma misdiagnosis in the past were taken into account in the analysis. Estimated risks of birth cohorts born after 1945 decrease less quickly in Italy than in other Western countries. The findings predict a peak with about 800 mesothelioma annual deaths in the period 2012–2024. Results estimated using age-period-cohort models were similar to those obtained from the asbestos consumption model.”
We all owe a debt of gratitude to these fine researchers for their important work. If you found any of these excerpts helpful, please read the studies in their entirety.
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