Mesothelioma and the Potential Accessibility of Tumors

Mesothelioma and the Potential Accessibility of Tumors

Mesothelioma and the Potential Accessibility of Tumors

Another interesting study is called, “Value of calretinin immunostaining in differentiating epithelial mesothelioma from lung adenocarcinoma.” By Ordóñez NG. The University of Texas M.D. Anderson Cancer Center, Houston 77030 – Mod Pathol. 1998 Oct;11(10):929-33.  Here is an excerpt: “Abstract – Only recently have immunohistochemical markers been recognized that are commonly expressed in epithelial mesotheliomas but not in adenocarcinomas. Among these, calretinin generated a great deal of interest, but the number of studies evaluating the practical use of calretinin immunostaining in the diagnosis of mesothelioma is limited, and the study results are controversial. To evaluate whether calretinin immunostaining can assist in distinguishing between epithelial pleural mesothelioma and lung adenocarcinoma and other carcinomas metastatic to the pleura, 38 pulmonary adenocarcinomas, 117 nonpulmonary adenocarcinomas, 28 squamous cell carcinomas of the lung, 8 large-cell undifferentiated carcinomas of the lung, and 9 transitional cell carcinomas metastatic to the lung were studied. Reactivity was observed in all of the 38 mesotheliomas, whereas only 3 of the 38 pulmonary adenocarcinomas and 11 of the 117 nonpulmonary adenocarcinomas (5/38 ovarian, 2/15 endometrial, 2/23 breast, 2/16 colonic, 0/8 kidney, 0/8 prostatic, 0/6 thyroid, and 0/3 pancreatic) exhibited weak or focal staining. Eleven of the 28 squamous carcinomas of the lung were also positive. No reactivity was observed in any of the large cell undifferentiated carcinomas of the lung or in the transitional cell carcinomas. It is concluded that calretinin immunostaining is not only helpful in discriminating epithelial pleural mesotheliomas from pulmonary adenocarcinomas but that it can also assist in distinguishing epithelial mesotheliomas from nonpulmonary adenocarcinomas metastatic to the pleura.”

Another interesting study is called, “Successful adenovirus-mediated gene transfer in an in vivo model of human malignant Mesothelioma” – The Annals of Thoracic Surgery Volume 57, Issue 6, June 1994, Pages 1395-1401 – by W.Roy Smythe MDa, Larry R. Kaiser MD, Harry C. Hwang BS, Kunjlata M. Amin PhD, Joseph M. Pilewski MD, Stephen J. Eck MD, PhD, James M. Wilson MD, PhD and Steven M. Albelda MD – Here is an excerpt: “Abstract – Malignant mesothelioma remains a frustrating clinical problem with uniformly poor responses to current therapeutic regimens. However, the localized nature of the disease, the potential accessibility of the tumor, and the relative lack of distant metastases make it a particularly attractive candidate for somatic gene therapy. The purpose of this study was to evaluate the ability of an adenoviral vector system to transfer genetic material to human mesothelioma cells in vitro and in vivo. Using a replication-deficient recombinant adenovirus carrying the Escherichia coli lacZ market gene, we found that human mesothelioma cell lines were susceptible to adenovirus infection. Furthermore, surprisingly effective gene transfer was accomplished within tumor implants of human mesothelioma growing within the peritoneal cavity c. immunodeficient mice after intraperitoneal administration of virus. These studies demonstrate that adenoviral vectors hold promise as vehicles to deliver gene therapy in human malignant mesothelioma.”

Another interesting study is called, “Immunohistochemical staining for vimentin and keratin in malignant Mesothelioma” by Churg, Andrew M.D; From the Department of Pathology, University of British Columbia, Vancouver, British Columbia, Canada.  May 1985 – Volume 9 – Issue 5 Here is an excerpt: “Abstract -  Because tissue culture studies have suggested that mesothelial cells might produce large amounts of vimentin, I stained eight mesotheliomas (two fixed in alcohol) for vimentin using the Gown and Vogel monoclonal antibody 43[beta] 8. The two tumors that had alcohol fixed blocks were strongly positive for vimentin, whereas one of the tumors fixed only in formalin showed moderately strong staining and two others showed very weak focal positivity; the remaining tumors were negative. In the mesotheliomas that did stain, both epithelial and spindled elements gave a positive reaction. Three alcohol-fixed lung cancers and two blocks of alcohol-fixed pleura failed to stain for vimentin. By contrast, all mesotheliomas and carcinomas, whether alcohol or formalin fixed, as well as sections of pleura, were strongly positive when stained with anticytokeratin antibody 35[beta] Hl 1. I conclude that the combination of staining for vimentin and keratin might be a useful diagnostic finding in malignant mesothelioma, but that specially fixed material is required for reliable vimentin staining.”

We all owe a debt of gratitude to these fine researchers.  If you found any of these excerpts interesting, please read the studies in their entirety.

Retrieved from “http://www.articlesbase.com/cancer-articles/mesothelioma-and-the-potential-accessibility-of-tumors-3389826.html

(ArticlesBase SC #3389826)

Montwrobleski77 -
About the Author:

Monty Wrobleski is the author of this article.  For more information please click on the following links

Depuy Hip Recall

Asbestos Disease

Depuy Hip Recall Attorney

]]>

Rate this Article

1
2
3
4
5

vote(s)
0 vote(s)

Feedback
RSS
Print
Email
Re-Publish

Source: http://www.articlesbase.com/cancer-articles/mesothelioma-and-the-potential-accessibility-of-tumors-3389826.html

Article Tags:
asbestos exposure, mesothelioma cancer, asbestos attorney, lawyer, class action lawyers, law suit, suite, law firm, law firms, litigation, treatment, lung cancer, patients, victims, meso lawyer, faq, navy veterans, symptoms, asbestos poisoning, damage, pl

Related Videos

Related Articles

Latest Cancer Articles
More from Montwrobleski77


Dr David Sanderson Explain Mesothelioma

Dr. David Sanderson describes mesothelioma and explains how asbestos contributes to lung cancer. (01:39)

Upper Lobe Tumors and Asbestos Exposure

Deaths due to mesothelioma could have been avoided

By:
Montwrobleski77l

Health>
Cancerl
Aug 21, 2010

Premature Death of Workers Caused by Asbestos Exposure and Mesothelioma

Spreading the word about asbestos related disease is the first step towards finding a cure

By:
Montwrobleski77l

Health>
Cancerl
Aug 21, 2010

Parenchymal Abnormalities Asbestos Exposure and Disease Development

Asbestos disease is deadly and more common than you think

By:
Montwrobleski77l

Health>
Cancerl
Sep 05, 2010

Peritoneal Mesothelioma Patients Generally Present with Two Types of Symptoms

Aberrant activation and upregulation of the Wnt pathway is a key feature of many cancers

By:
Montwrobleski77l

Health>
Cancerl
Oct 02, 2010

Peripheral Tumours Mesothelioma Disease Development and Asbestos Exposure

The majority of cases with asbestos-related diseases had experienced their first asbestos exposure prior to 1960. For cases with first asbestos exposure after 1960, a shift was observed from the primary asbestos industry towards asbestos-using industries

By:
Montwrobleski77l

Health>
Cancerl
Sep 20, 2010

Asbestos Exposure and Ferruginous Bodies in the Lungs

Asbestos has been documented as a contaminant of some older cosmetic talc preparations, the chrysotile and crocidolite types of asbestos are more indicative of background and occupational exposure

By:
Montwrobleski77l

Health>
Cancerl
Sep 19, 2010

Asbestos Exposure and Human Mesothelioma Cell Lines

Recently two antifolate-based combinations with apparently higher efficacy than older regimens have emerged: the pemetrexed/cisplatin regimen and the raltitrexed/oxaliplatin regimen

By:
Montwrobleski77l

Health>
Cancerl
Oct 22, 2010

Mean Durations of Asbestos Exposure and Chest Abnormalities

It is believed that a program of medical awareness should be instituted in work areas where people are employed in the mining, processing and use of asbestos

By:
Montwrobleski77l

Health>
Cancerl
Sep 19, 2010

Beginners Enjoy Meditation

Meditation is also a great accompaniment to massages and spa treatments.

By:
Tom Mackl

Health>
Cancerl
Nov 08, 2010

Meditation Is Good For Your Health

You can meditate for a few minutes first thing in the morning or at night before bed.

By:
Tom Mackl

Health>
Cancerl
Nov 08, 2010

Bharatbook – Worldwide Top 20 Cancer Therapy Brands

Bharatbook added a new report on “Commercial Insight: Top 20 Cancer Therapy Brands” which gives leading cancer brands and drug classes to identify key success factors within this sector.

By:
bharatbookl

Health>
Cancerl
Nov 08, 2010

Mesothelioma Treatment

This article gives a brief description of Mesothelioma, and discusses treatment options

By:
Mikasl

Health>
Cancerl
Nov 07, 2010

Influences of environmental chemicals on breast cancer

For millions of women whose lives have been affected by breast cancer, the 1994 discovery of the first breast cancer gene by researchers from the National Institute of Environmental Health Sciences (NIEHS) was a welcome sign of progress in the fight against this dreaded disease. Statistics tell us that breast cancer is still a major health concern for women everywhere. More women in INDIA are living with breast cancer than with any other non-skin cancer.

By:
Dr.R.Uma Ranil

Health>
Cancerl
Nov 07, 2010

You can’t escape disease unless you have this

Sir / Madam Let’s face it. No one in this country – not you, me, or anyone else in the world, for that matter — is unaffected by disease. Some of us have suffered from disease ourselves, and practically every one of us has a loved one who is (or has been) a victim of a devastating disease — or even died from it.

By:
Januszl

Health>
Cancerl
Nov 07, 2010

Do you or a loved one suffer from Lung Cancer

Compensation is already being recovered on behalf of thousands of patients and families of those exposed to asbestos and diagnosed with lung cancer. Contact our legal team before it’s too late

By:
Mahmoud Hamdyl

Health>
Cancerl
Nov 06, 2010

Breast Cancer Ribbon

Breast cancer are all breast cancers that afflict the human body. Several rare types of cancer of the breast can strike people as well. Invasive, or infiltrating, ductal carcinoma is the most common, making up 70 percent of all breast cancer cases. For awareness in women the Breast Cancer Ribbon is used. This ribbon is in pink color.

By:
Muqeet Somrol

Health>
Cancerl
Nov 05, 2010

Mesothelioma Therapy with the Antiestrogen Tamoxifen

Therapy with the antiestrogen tamoxifen in this setting may provide an option for long-term medical management in cases of symptomatic recurrent cystic mesotheliomas

By:
Montwrobleski77l

Health>
Cancerl
Oct 28, 2010

Mesothelioma and Histological Evidence of Extra Pleural Lymph Node Metastases

Pathological nodal involvement cannot be predicted from nodal dimensions. These data suggest that all patients being considered for radical resection of MPM should preferentially undergo preoperative cervical mediastinoscopy irrespective of radiological findings

By:
Montwrobleski77l

Health>
Cancerl
Oct 28, 2010

Do Markers Provide Higher Diagnostic Accuracy for Mesothelioma

Various antibody panels have been recommended for the diagnosis of MM, with no overall consensus about how many and which markers should be used. A recent study with Bayesian statistics has demonstrated that the use of many markers does not provide higher diagnostic accuracy than the use of selected single antibodies or various combinations of only 2 markers

By:
Montwrobleski77l

Health>
Cancerl
Oct 28, 2010

Mesothelioma and Effects of Epigenetic and Genetic Alterations

Although the association between TSP-1 and VEGF has not been well defined, the effect of VEGF should be considered when attempting to determine the impact of TSP-1 on prognosis

By:
Montwrobleski77l

Health>
Cancerl
Oct 28, 2010

Mesothelioma Cell Lines Using Indirect Immunofluorescence and Northern Blotting

Many controversial issues still exist in the treatment of malignant pleural mesothelioma. In the ensuing years newer staging systems, better preoperative staging, newer experimental therapies, and the localization of patients at expert centers will undoubtedly have an impact on disease management.

By:
Montwrobleski77l

Health>
Cancerl
Oct 27, 2010

Mesothelioma and Continuous Infusion Paclitaxel Administered with Large Field Irradiation

Together with identification of the antigen in serum, pleural fluid, or ascitic fluid, immunohistochemical and immunocytochemical techniques for detecting carcinoembryonic antigen provide a valuable aid for distinguishing malignant mesothelioma from metastatic carcinomas.

By:
Montwrobleski77l

Health>
Cancerl
Oct 27, 2010

Mesothelioma Multimodality Approach with CAP Chemotherapy

The use of extrapleural pneumonectomy in a multimodality treatment setting for malignant pleural mesothelioma is described, presenting first the right-sided approach and then the left-sided. This technique used in a multimodality approach with CAP chemotherapy.

By:
Montwrobleski77l

Health>
Cancerl
Oct 27, 2010

Mesothelioma and Murine Models of Melanoma and Adenocarcinoma

There is good evidence to recommend chemotherapy with pemetrexed and cisplatin for adult patients with symptomatic advanced malignant pleural mesothelioma. Such treatment should be administered with supplementation of vitamin B12 and folic acid

By:
Montwrobleski77l

Health>
Cancerl
Oct 27, 2010

Add new Comment

Your Name: *

Your Email:

Comment Body: *

Verification code:*

* Required fields

Submit

Your Articles Here
It’s Free and easy

Sign Up Today

Author Navigation

My Home
Publish Article
View/Edit Articles
View/Edit Q&A
Edit your Account
Manage Authors
Statistics Page
Personal RSS Builder

My Home
Edit your Account
Update Profile
View/Edit Q&A
Publish Article
Author Box


Montwrobleski77 has 234 articles online

Contact Author

Subscribe to RSS

Print article

Send to friend

Re-Publish article

Articles Categories
All Categories

Advertising
Arts & Entertainment
Automotive
Beauty
Business
Careers
Computers
Education
Finance
Food and Beverage
Health
Hobbies
Home and Family
Home Improvement
Internet
Judaism
Law
Marketing
News and Society
Relationships
Self Improvement
Shopping
Spirituality
Sports and Fitness
Technology
Travel
Writing

Health

Acne
Allergies
Alternative Medicine
Anti Aging
Cancer
Dental Care
Disabilities
Diseases and Conditions
Hair Loss
Hearing
Medical Tourism
Medicine
Men’s Health
Mental Health
Nutrition
Plastic Surgeries
Quit Smoking
Sleep
Supplements & Vitamins
Vision
Wellness
Women’s Health

]]>

Need Help?
Contact Us
FAQ
Submit Articles
Editorial Guidelines
Blog

Site Links
Recent Articles
Top Authors
Top Articles
Find Articles
Site Map

Webmasters
RSS Builder
RSS
Link to Us

Business Info
Advertising

Use of this web site constitutes acceptance of the Terms Of Use and Privacy Policy | User published content is licensed under a Creative Commons License.
Copyright © 2005-2010 Free Articles by ArticlesBase.com, All rights reserved.

Monty Wrobleski is the author of this article.  For more information please click on the following links

Depuy Hip Recall

Asbestos Disease

Depuy Hip Recall Attorney
Article from articlesbase.com

Comments are closed.

Categories