Mesothelioma Cancer Treatment. Heated Intraoperative Intraperitoneal Chemotherapy

Mesothelioma Cancer Treatment. Heated Intraoperative Intraperitoneal Chemotherapy

Mesothelioma Cancer Treatment. Heated Intraoperative Intraperitoneal Chemotherapy


Free Online Articles Directory





Why Submit Articles?
Top Authors
Top Articles
FAQ
AB Answers

Publish Article

0 && $ .browser.msie ) {
var ie_version = parseInt($ .browser.version);
if(ie_version Hello Guest
Login


Login via


Register
Hello
My Home
Sign Out

Email

Password


Remember me?
Lost Password?

Home Page > Health > Cancer > Mesothelioma Cancer Treatment. Heated Intraoperative Intraperitoneal Chemotherapy

Mesothelioma Cancer Treatment. Heated Intraoperative Intraperitoneal Chemotherapy

Edit Article |

Posted: Oct 06, 2009 |Comments: 0
| Views: 107
|

Share

]]>

Syndicate this Article

Copy to clipboard

Mesothelioma Cancer Treatment. Heated Intraoperative Intraperitoneal Chemotherapy

By: alex

About the Author

http://mesotheliomacancertreatmentcom.blogspot.com/

(ArticlesBase SC #1307572)

Article Source: http://www.articlesbase.com/Mesothelioma Cancer Treatment. Heated Intraoperative Intraperitoneal Chemotherapy





Heated Intraoperative Intraperitoneal Chemotherapy Mesothelioma Cancer Treatment

A procedure known as heated intraoperative intraperitoneal chemotherapy was developed by Paul Sugarbaker at the Washington Cancer Institute.The surgeon removes as much of the tumor as possible followed by the direct administration of a chemotherapy agent, heated to between 40 and 48°C, in the abdomen. The fluid is perfused for 60 to 120 minutes and then drained.

This technique permits the administration of high concentrations of selected drugs into the abdominal and pelvic surfaces. Heating the chemotherapy treatment increases the penetration of the drugs into tissues. Also, heating itself damages the malignant cells more than the normal cells.

Dr. Paul Sugarbaker, renowned oncologic surgeon specializing in mesothelioma at the Washington Cancer Institute, developed a leading-edge surgical procedure to treat mesothelioma called heated intraoperative intraperitoneal chemotherapy. In this procedure, as much of the tumor as possible is first removed by the surgeon. Following the removal of the tumor, a chemotherapy agent heated to between 40°C and 48°C is administered into the abdomen. The fluid is perfused for anywhere between one and two hours and then it is drained.

High concentrations of selected drugs can be administered into the abdominal and pelvic surfaces using this technique. The other benefit associated with using this technique to treat peritoneal mesothelioma is that the heated chemotherapy treatment increases the level to which the drugs can penetrate the tissues and damages malignant cells more than normal ones.

Coliseum Technique for Hyperthermic Intraoperative Intraperitoneal Chemotherapy


Cytoreductive surgery was attempted to make each patient macroscopically disease-free. At the end of the procedure, four closed suction catheters (Zimmer Inc, Warsaw, IN) were placed through the abdominal wall, using stab incisions, to lie beneath each hemidiaphragm and two within the pelvis (Figure 2). A Tenckhoff catheter (Quinton Inc, Seattle, WA) was placed through the abdominal wall if early postoperative intraperitoneal chemotherapy (EPIC) is planned. Otherwise, the Tenckhoff catheter was placed over the midline abdominal incision for use in HIIC. The Tenckhoff catheter functioned as an in-flow line. The closed suction catheters were used as drainage lines for intraoperative lavage and remained in place for postoperative abdominal drainage. Two temperature probes (Respiratory Support Products Inc. Irvine, CA) were then placed over the edge of the abdominal incision. One temperature probe was tied to the Tenckhoff catheter. The other temperature probe was tied to a closed suction drain at a distant location from the Tenckhoff. All transabdominal tubes were secured to the skin and to the peritoneum with purse string sutures to prevent fluid leakage. The Thompson retractor (Thompson Surgical Instruments, Traverse City, MI) was then repositioned as in Figure 2. The abdomen was left open with the skin edges suspended to the Thompson retractor with a number 2 running nylon suture. To prevent spillage of the chemotherapy and to control potential chemotherapy vapors, a plastic sheet was sutured to the wound edges. A slit incision was then made in the center of the plastic sheet to allow the surgeon access to all intraabdominal surfaces and to manually control the fluid distribution. After the hyperthermic perfusion was complete, bowel anastomoses and other reconstructive procedures were performed.

The hyperthermic perfusion with mitomycin C was carried out for ninety minutes using a HIIC custom tubing pack (Bard Cardiology, Haverhill, MA), two cardiopulmonary bypass pumps (Travenol Labs, Morton Grove, IL) and a Sarns heater/cooler unit (3M Cardiovascular Systems, Ann Arbor, MI). Three liters of 1.5% dextrose peritoneal dialysis solution containing the appropriate cytotoxic drug(s) were heated and infused at approximately 1 liter per minute into the abdominal cavity. The perfusate was heated to approximately 43oC. Temperatures were measured with a Labcraft digital thermometer (Curtin Matheson Scientific, Jessup, MD). The temperature at the In-Flow line was approximately 44oC. The Tenckhoff temperature probe was maintained between 42 and 43oC. The temperature probes and all temporary 3-0 chromic sutures were removed at the end of the hyperthermic perfusion.

Urine output was monitored by the anesthesiologist. At his or her discretion fluid challenge, furosemide, renal dose dopamine or mannitol were instituted to maintain a brisk diuresis. Urine output was measured every 15 minutes. It was maintained at greater than 400 cc per hour during the ninety minutes of the hyperthermic perfusion and for one hour thereafter.

In addition to intraoperative hyperthermic perfusion, patients with high grade tumor or incomplete cytoreduction received five days of early postoperative intraperitoneal chemotherapy. These five days of chemotherapy were given on postoperative days 1-5. Each dose was prepared in 1000 to 2000 cc of 1.5% dextrose peritoneal dialysis solution, depending on body size. Each dose was infused as quickly as possible, allowed to dwell for 23 hours then drained for one hour prior to the next infusion.

Levels of 5-FU were monitored in the peritoneal fluid and plasma of 9 patients on the first postoperative day. Three patients received cytoreductive surgery, HIIC and early postoperative 5-FU. Six patients received only cytoreduction and early postoperative 5-FU. Samples were obtained at regular intervals from 0 to 180 minutes post infusion.

Drug doses were as follows:

For pseudomyxoma peritonei and adenocarcinoma from appendiceal, colonic and rectal cancer:

Drug Day Route Dose Mitomycin C 0 IP 12.5 mg/m2 (max. 25 mg) for males or
10.0 mg/m2 (max 20 mg) for females in 3 liters. 5-Fluorouracil 1-5 IP 15 mg/m2 x 5 days

For gastric, pancreatic and ovarian cancer, mesothelioma, and sarcoma:

Drug Day Route Dose Cisplatin 0 IP 50 mg/m2 (max. 100 mg) Doxorubicin 0 IP 50 mg/m2 (max. 100 mg) Mitomycin C 0 IP 7 mg/m2 (max. 14 mg)

Doxorubicin 1-5 IP 15 mg/m2 x 5 days

Standardized dose reductions occurred as follows:

33% dose reduction for age > 65 years
33% dose reduction for patients with compromised renal function.
50% dose reduction for prior exposure to heavy chemotherapy or radiation therapy
Other dose reductions as deemed necessary by the Principal Investigator.

For patients undergoing pharmacokinetic monitoring, samples of plasma, urine and perfusate were obtained at fifteen minute intervals during the hyperthermic perfusion and at the end of the procedure. These measurements were used for pharmacokinetic calculations and to help relate possible complications to systemic and intraperitoneal drug levels.

Patients were monitored for complications associated with intraperitoneal hyperthermia including: enteral complications (fistulas, anastomotic leaks), wound complications (pancreatitis, bile leaks, wound dehiscence), hematologic toxicities, prolonged ileus and line sepsis.

Retrieved from “http://www.articlesbase.com/cancer-articles/mesothelioma-cancer-treatment-heated-intraoperative-intraperitoneal-chemotherapy-1307572.html

(ArticlesBase SC #1307572)

alex -
About the Author:

http://mesotheliomacancertreatmentcom.blogspot.com/

]]>

Rate this Article

1
2
3
4
5

vote(s)
0 vote(s)

Feedback
RSS
Print
Email
Re-Publish

Source:  http://www.articlesbase.com/cancer-articles/mesothelioma-cancer-treatment-heated-intraoperative-intraperitoneal-chemotherapy-1307572.html

Article Tags:
mesothelioma, treatment, radiation therapy, chemotherapy, gene therapy treat, peritoneal, malignant, photodynamic, updates lung, cancer, immunotherapy, asbestos

Related Videos

Latest Cancer Articles
More from alex


Chemotherapy Treatments – Paula’s Story

Paula shares the chemotherapy treatments she had after relapsing. (00:51)


Chemotherapy Treatment – Dona’s Story

Dona shares the chemotherapy treatment she had for ovarian cancer. (01:39)


Ovarian Cancer Chemotherapy – Paula’s Story

Paula shares her ovarian cancer chemotherapy experience and how she felt. (04:09)


How Lung Cancer Patients Receive Radiation and Chemotherapy

Dr. David Sanderson shares how radiation and chemotherapy treatments are administered to lung cancer patients. (01:13)


Natural Cancer Treatment and Chemotherapy Compared

Dr. Abrams explains if a woman is making a mistake if she chooses a natural course of Treatment for cancer instead of having chemotherapy. (01:21)

Discover Natural Ways to Stop Snoring

Try to stay away from relaxants like drugs, alcohol, cigarettes, and other medications because they are known to influence your snoring.

By:
Tom Mackl

Health>
Cancerl
Nov 11, 2010

Lung Cancer Therapies

Lung cancer is a benign tumor in the lungs. It is the leading cause of cancer related deaths among men and women.

By:
wendyl

Health>
Cancerl
Nov 11, 2010

Breast Cancer Awareness

This October is the month of the Breast Cancer Awareness. Lots of people are going to cooperates in this event through wearing pinks. It is very important that we became a part of this kind of events, to educate people around the globe about this kind of illness.

By:
kimberly valeriol

Health>
Cancerl
Nov 11, 2010

Thyroid Cancer, “A Real Cancer”

Unless you have a goiter or an obvious cyst growing on your thyroid gland, it can be hard to believe that you really have thyroid cancer when diagnosed. A lot of times there are no obvious symptoms.

By:
Elaine Savardl

Health>
Cancerl
Nov 10, 2010

EFX Stays A”Breast” Of Cancer Awareness Throughout October

EFX Performance, Inc.’s advocacy for breast cancer awareness in October 2010

By:
James Chisuml

Health>
Cancerl
Nov 10, 2010

How to Improve Posture While Sitting At a Desk

The call center finance department can save up money if they are getting the right kind of ergonomics for the call centers.

By:
ShawnClerkl

Health>
Cancerl
Nov 10, 2010

8 Things That You Didn’t Know Could Cause Cancer

Most people can easily name a few things that they know cause cancer such as tobacco use or air pollution. However, this article features 8 factors that many do not realize are serious potential cancer triggers. These are factors that researchers have determined can measurably influence cancer risk.

By:
Julie Joycel

Health>
Cancerl
Nov 09, 2010

Breast Cancer Alerts

With the rate at which the disease is increasing its prominence, it has become very important to spread awareness against this ailment. Breast cancer awareness programme have been initiated in different places with a motive to protect and create awareness about the disease amongst women. October is recognized as National Breast Cancer Awareness Month around the world.

By:
Tony J Porterl

Health>
Cancerl
Nov 09, 2010

The budding risk of asbestos to health

People who are constantly faced with asbestos, in support of model, in the process of its stock and processing, as properly as during working with asbestos-containing materials (in particular – while erection when raw and etc. operations involving the set-up of dust) and not alluring adequate measures to keep safe against dust may reveal asbestosis – a slowly progressing lungs’ fibrosis. Asbestosis is lone of the lung pulmonary diseases

By:
alexl

Health>
Cancerl
May 22, 2010

Receiver gloves

Previously the FIFA World Cup 1970, the goalkeepers almost never wear football receiver gloves while playing, right now you can hardly see them with no goalkeeper gloves. In addition to the gloves reliably defend your hands, mitigating the contact, they also give a better grip with the palms of the ball. Than younger the player, is that more valuable for him hands safety.

By:
alexl

Sports and Fitness>
Footballl
May 22, 2010

Mesothelioma asbestos cancer

Hi. My name is alex. My site http://mesotheliomamesothelium.com/

By:
alexl

Health>
Cancerl
Oct 19, 2009

Mesothelioma

Hi

By:
alexl

Health>
Cancerl
Oct 18, 2009

Mesothelioma Cancer Treatment. Heated Intraoperative Intraperitoneal Chemotherapy

Mesothelioma Cancer Treatment. Information about Mesothelioma Cancer Treatments: Drugs, Immunotherapy, Chemotherapy, Radiation, Surgery Treatments and Heated Intraoperative Intraperitoneal Chemotherapy.

By:
alexl

Health>
Cancerl
Oct 06, 2009
lViews: 107

Add new Comment

Your Name: *

Your Email:

Comment Body: *

 

Verification code:*

* Required fields

Submit

Your Articles Here
It’s Free and easy

Sign Up Today

Author Navigation

My Home
Publish Article
View/Edit Articles
View/Edit Q&A
Edit your Account
Manage Authors
Statistics Page
Personal RSS Builder

My Home
Edit your Account
Update Profile
View/Edit Q&A
Publish Article
Author Box


alex has 5 articles online

Contact Author

Subscribe to RSS

Print article

Send to friend

Re-Publish article

Articles Categories
All Categories

Advertising
Arts & Entertainment
Automotive
Beauty
Business
Careers
Computers
Education
Finance
Food and Beverage
Health
Hobbies
Home and Family
Home Improvement
Internet
Judaism
Law
Marketing
News and Society
Relationships
Self Improvement
Shopping
Spirituality
Sports and Fitness
Technology
Travel
Writing

Health

Acne
Allergies
Alternative Medicine
Anti Aging
Cancer
Dental Care
Disabilities
Diseases and Conditions
Hair Loss
Hearing
Medical Tourism
Medicine
Men’s Health
Mental Health
Nutrition
Plastic Surgeries
Quit Smoking
Sleep
Supplements & Vitamins
Vision
Wellness
Women’s Health

]]>

Need Help?
Contact Us
FAQ
Submit Articles
Editorial Guidelines
Blog

Site Links
Recent Articles
Top Authors
Top Articles
Find Articles
Site Map

Webmasters
RSS Builder
RSS
Link to Us

Business Info
Advertising

Use of this web site constitutes acceptance of the Terms Of Use and Privacy Policy | User published content is licensed under a Creative Commons License.
Copyright © 2005-2010 Free Articles by ArticlesBase.com, All rights reserved.

http://mesotheliomacancertreatmentcom.blogspot.com/


Article from articlesbase.com

More Mesothelioma Cancer Treatment Articles

Comments are closed.

Categories