Posts Tagged ‘Biomarkers’

Mesothelioma Cancer Researchers Eye Biomarkers for Treatments

Mesothelioma Cancer Researchers Eye Biomarkers for Treatments

Copyright (c) 2008 Katie Kelley

A study from the Department of Molecular Pathology at the Polytechnic University of Marche in Acona, Italy recently found that biomarkers within the body may offer early warning signs for mesothelioma victims.

The study focused on biomarkers of mesothelioma cancer and found that biomarkers often form before mesothelioma cancer symptoms appear, which may offer early warnings and potentially a successful treatment for mesothelioma cancer patients, according to the study which was published in a June issue of Mutation Research.

Studying Biomarkers to Help Mesothelioma Treatment

Biomarkers are a type of “biochemically expressed substance” similar to a protein, according to a news report on the study. An effort is being collaborated on by the International Cancer Biomarker Consortium (ICBC) to better address biomarkers as indicators of cancer types such as mesothelioma.

The large-scale effort is similar, according to the ICBC, to the Human Genome Project and uses an array of researchers from around the world to assist in studying the use of the the biomarkers. The Polytechnic study followed 119 individuals who had been previously exposed to asbestos; of these individuals, all exhibited increased numbers of biomarkers compared to individuals who were not exposed to asbestos.

What is Mesothelioma Cancer

Mesothelioma is a type of lung cancer that can develop after an individual is exposed to asbestos fibers or asbestos dust. After an individual is exposed to asbestos fibers, they may begin to develop cancerous cells on the interior lining of the lung. The cancer is often described as one of the only preventable forms of cancer especially since individuals are still being exposed to asbestos in America through improper cleanup and disposal methods. Asbestos can be found presently in an array of buildings including apartment complexes, homes, elementary schools, universities, hospitals and offices.

Unfortunately, individuals continue to be exposed to asbestos fibers because of its existence in many products implemented throughout the country, and because it is too costly to remove all asbestos by the Environmental Protection Agency (EPA), many remain at risk. Additionally, because mesothelioma cancer usually remains dormant for years, it becomes increasingly difficult to diagnose and to successfully treat.

Finding Help for Asbestos Related Conditions Like Mesothelioma

It is important that individuals who may have been exposed to asbestos to contact a medical professional immediately to assess and potentially diagnose their condition. If mesothelioma cancer is diagnosed early on a mesothelioma victim has a better chance of decreasing the risks of fatality commonly associated with the cancer.

In addition to contacting a medical professional it may also be important to contact an experienced mesothelioma attorney to learn about developing a mesothelioma lawsuit, which may result in receiving monetary compensation to pay for expensive mesothelioma medical bills.

The latest on mesothelioma can be found at or at Additionally, victims of truck accident injuries or those needing an Avandia attorney can also use the site to better understand their situation and how to overcome their legal problems.

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Biomarkers helping to advance of research into diagnosing mesothelioma

Biomarkers helping to advance of research into diagnosing mesothelioma

Research experts in Germany have made progress in the use of biomarkers to help diagnose patients suffering from mesothelioma.

Mesothelioma is just one type of cancer that affects parts of the thin membrane which is located on the inner surface of the chest wall. It is a disease that has affected many people in the UK who came into contact with asbestos through their work. Despite the potential risks of working with asbestos being known, some industries continued to use the product and yet did not provide employees with suitable safety equipment to protect their health.

Shipbuilders, carpenters, roofers, plumbers, painters and demolition workers are just some of the workers who came into contact with asbestos. However it is not just workers who have developed mesothelioma, family members and friends who have handled clothes that have been in contact with asbestos have also been known to become sufferers. In addition, the symptoms of mesothelioma can take up to 50 years to materialise.

The research centred on the biomarker calretinin and looked at its potential use as a diagnostic tool in human blood. The aim was to develop an “enzyme-linked immunosorbent assay (ELISA) for human calretinin in blood” and then consider its potential as a diagnostic marker for malignant mesothelioma.

According to the mesothelioma resource site, samples were taken from 97 healthy people, 35 people who were exposed to asbestos through their work and 42 patients suffering from malignant mesothelioma.

The researchers concluded that calretinin levels were found to be significantly higher in patients who were suffering from malignant mesothelioma. They said this suggests that the biomarker might be suitable for the blood-based detection of the disease, possibly alongside other biomarkers such as mesothelin. The research team said the results provide a promising basis for the validation of calretinin as a biomarker for MM in larger case-control as well as prospective studies.

Biomarkers are becoming an increasingly important diagnostic tool in terms of medical research, helping scientists to develop tests to spot the presence of diseases and hopefully in turn identify sufferers at an early stage so medication can be provided to minimise the effects. Much more research remains to be done, but there is little doubt that biomarkers will continue to play a significant role.

The results show just how important it is that more work is put into biomarker research and into building a biomarkers database that can help advance knowledge and diagnosis techniques.

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