Posts Tagged ‘Disease’

Mesothelioma : Dealing With This Deadly Disease

Mesothelioma : Dealing With This Deadly Disease

If you are dealing with Mesothelioma, don’t lose hope yet. Although this is considered to be an incurable disease, it is by no means the end of your life altogether. You can still look forward to the remaining time that you are around and ensure that you spend them in the right away. People who lose interest in living after being diagnosed with such conditions are essentially giving up the fight even before it has started. Hence, you shouldn’t be such an individual and should learn to do what it takes in order to enjoy the rest of the time you are here.

Joining A Support Group

One of the first things that you would probably want to do is to join a support group that helps people deal with Mesothelioma. There are a number of these around, both online as well as in big neighborhoods. You might have to track them down to spend time with others that have been diagnosed with this condition too. In this manner, you will not be the only one with the disease and will have other people around you for support as well. Initially, you might not be inclined towards this. But, with time, you are guaranteed to like this option and might even go in for it.

Learning More About It

Another thing that you might want to consider is that you would probably want to research more about the condition and know more about how it might affect you. In this way, you can be sure about what to expect and what you can do in order to alleviate the pain. The more you know about Mesothelioma, the less likely it is that you are going to be in suspense about it. Sometimes they say ignorance is bliss, but in this case, it is highly advised to learn more about it so that you are not left hanging in suspense.

Seeking Support From Close Friends

If you haven’t done so already, you might want to seek support from those that are close to you. Your family and your friends are great sources of support to help ensure that you are actually able to enjoy your remaining time. Most patients find immense joy in just spending time with their loved ones. They even say that they feel rejuvenated in doing so. Hence, despite being diagnosed with Mesothelioma, you should be aware that you are not all alone and that it is very much possible for you to lead a healthy and normal life.

There are a number of life threatening diseases out there and malignant mesothelioma is just one of them. Simply giving up hope and not doing anything about it is worse than dying from the disease. Ensure that you do get adequate support and that the people around you are there to support you. In a number of ways, the people are known to feel a lot better by simply being with the ones they are close to. You too should find something that you truly cherish and look forward to doing that for the period after diagnosis.

For learning more about mesothelioma and what to do after being detected, go to the site mesotheliomahelp.net/about-mesothelioma.html


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Mesothelioma Cancer Disease ? How to Overcome the bitter disease!

Mesothelioma Cancer Disease ? How to Overcome the bitter disease!

There is a new hope for Mesothelioma patients. Health! they say is wealth; it has now being proved that the disease known as mesothelioma affects the diaphragm and other internal organs and especially the lining of the abdomen (peritoneum) called the peritoneal mesothelioma, can now be treated by some specialist doctors known as mesothelioma specialist doctors.

Mesothelioma patients usually have a prior working relationship in asbestos factories and the life span of the infected patients from the time of infection until death; if not quickly treated is averagely less than 24 months. This disease can be treated in the early stage when the symptoms begin to show up.

It occurs after some several weeks of which the asbestos virus was been inhaled into the lungs and it usually show up with the following symptoms:

i. Shortness of breath,
ii. Pain in chest/abdomen or
iii. Swelling in the abdomen.
As soon as any of the symptoms above is observed; the early the disease can be overcome before it gets worse. The doctor will perform thorough medical tests and if diagnosed any type of mesothelioma disease, he will then act fast to eliminate the cancer at early stage.

Following are the stages of the mesothelioma cancer infection:

1. Local stage – Found in the lining of the chest cavity or in the diaphragm or the lungs,
2. Stage II – Found beyond the chest lining to lymph nodes,
3. Stage III – Spread to the chest wall, center of the chest, heart, through the diaphragm or abdominal lining,
4. Stage IV – It goes beyond the thoracic cavity, as far as to the covering layer of the testicles.

Peritoneal mesothelioma affects the muscle around the heart (pericardium cavity) is called the pericardial mesothelioma. Tumors of the mesothelioma can either be benign (non cancerous) or malignant (cancerous).

There were many patients who received full treatments and completely healed when handled early. It is wise and safe to observe the problem as early as possible and meet the specialist doctor for treatment.

Delay can be very dangerous. You may find the listing of the mesothelioma doctors here to consult series of them online to tell them what and what you observed in your body when invited, you can meet the one closed to your home for full medical checkup and immediate treatment if need be.


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Malignant Mesothelioma: Myths About This Disease

Malignant Mesothelioma: Myths About This Disease

There are so many different complications that can cause the human body to get worn out and stop functioning like it normally would. The one kind of disease that people ought to be really cautious about would probably have to be malignant Mesothelioma. While there are some things about this disease that is well known, there are certain other rumors that are attached to it as well. Hence, it is important to get rid of these rumors and ensure that you don’t simply pay heed to the wrong kind of information. Listed below are some common myths that people often end up believing.

Contracted from lifestyle choices

While cancer itself is often associated with the bad choices that people make during the course of their life, not all forms of it are considered to be deadly. In fact, there are certain kinds of cancers that can be caused for no fault of the individual whatsoever. One such form would probably have to be malignant Mesothelioma. This is not caused or worsened because of the individual smoking or doing something by choice. It is often caused due to a high exposure of asbestos several years ago. Hence, the condition has quite a large dormant period before you can see any visible symptoms.

Can be completely cured

Unfortunately, chemotherapy or even going in for cures that are normally prescribed for other kinds of cancer will not help you out here. You might have to take solace in the fact that your pain can be reduced with the medicine, but little else can be done about everything else. Hence, this is a form of cancer that you might really not be able to cure completely for the time being. Malignant Mesothelioma is going to cause your health to deteriorate gradually, causing you to slip into coma and even death in extreme cases.

Can be contracted from the individual

Considering the nature of the disease and how it can affect individuals that don’t even smoke, it is natural for people to think that they can contract it by simply hanging around individuals with this condition. This is completely false, as malignant Mesothelioma is bought about due to an overwhelming presence of asbestos and little else. Hence, it cannot simply be passed from an individual to another by simply breathing from the same space. It takes much more to contract it, and you can be rest assured that the person diagnosed with this condition is absolutely safe to hang around with.

Hence, this should hopefully have busted some myths about the disease that have been floating around. There are many more things associated with malignant mesothelioma that is often believed to be true, but seldom is correct. Hence, it is strongly recommended to research into the condition before you can go ahead and decide on what you might consider to do about the disease. Keep in mind that you might have to be cautious and not simply pay heed to anything that you hear about. Trusting a reliable source for information is the best thing that you can do.

A great website that you can go in order to learn more about malignant mesothelioma is mesotheliomahelp.net/about-mesothelioma.html.


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Understanding Mesothelioma Cancer Disease

Understanding Mesothelioma Cancer Disease

What is mesothelioma? Mesothelioma cancer disease is a very rare type on cancer, but it can be very dangerous and has a very deadly effect. This cancer can develop in the mesothelial cells that compose the most outer layers of some internal organs.

What are the types of mesothelioma cancer? The types of mesothelioma can be divided into main three types according to the place of the affected internal organs; the most common type of this cancer is when the tumors are developed in the pleura “the outer lining of lungs”. A less common type is the pericardial mesothelioma when the tumors are developed in the pericardium or the sac of the heart and its arteries.

The third mesothelioma type is the peritoneal mesothelioma where the tumors are developed in the peritoneum or the outer lining that surrounds the internal organs of the abdominal cavity. These were the main three types, there is another type that called benign mesothelioma and in this case the tumors that developed are nonmalignant.

What is the main cause of mesothelioma? The main cause of mesothelioma is some natural minerals called “Asbestos”. These Asbestos can be inhaled and cause inflammation of the pleural leading to malignant tumors after 15 to 25 years. The symptoms of mesothelioma take very long time to appear, as I mentioned, they may take up to 25 years to appear that make the diagnosis process is very hard.

What are the main treatment options for mesothelioma cancer? Actually, there are many treatment options for mesothelioma cancer, but the main options to treat mesothelioma are the surgery option, the chemotherapy option and the radiotherapy option. If you were dealing with Asbestos before, please consult your doctor today.

By Husseiny Ahmed, know everything about Mesothelioma Cancer now.


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A Short History of Occupational Disease in the United States

A brief look at the origin of occupational medicine in the US in the early Twentieth century. This clip is taken from the 1979 film, “Can’t Take No More,” by OSHA. This excellent 27 minutes film is available on GoogleVideo.
Video Rating: 5 / 5

Chrysotile Stimulated UPA Activity and Mesothelioma Disease

Chrysotile Stimulated UPA Activity and Mesothelioma Disease

One interesting study is called, “Expression and Activity of Urokinase and Its Receptor in Endothelial and Pulmonary Epithelial Cells Exposed to Asbestos” by Aaron Barchowsky, Robert R. Roussel, Ronald J. Krieser, Brooke T. Mossman and Melinda D. Treadwell – Toxicology and Applied Pharmacology – Volume 152, Issue 2, October 1998, Pages 388-396.  Here is an excerpt: “Abstract – An elongated endothelial cell phenotype, which demonstrated increased ICAM-1-dependent neutrophil adherence, was induced when these cells were exposed to noncytotoxic concentrations of asbestos (Treadwellet al., Toxicol. Appl. Pharmacol.139, 62–70, 1996). The present study examined mechanisms underlying this phenotypic change by investigating the effects of asbestos on transcription factor activation and expression of urokinase-type plasminogen activator (uPA) and its receptor uPAR.In situzymography was used to compare the effects of these fibers on the activity of uPA. Cultures incubated with chrysotile or crocidolite asbestos, but not refractory ceramic fiber 1 (RCF-1), demonstrate localized cleavage of plasminogen, which was inhibited by amiloride. Immunocytochemistry showed that chrysotile-stimulated uPA activity was associated with a time-dependent augmentation of uPAR protein levels. RT–PCR analysis was used to investigate molecular mechanisms for these increases. Chrysotile asbestos, but not RCF-1, increased endothelial cell uPA message, relative to changes in β-actin mRNA. This response to asbestos was not limited to endothelial cells, since both uPA and uPAR mRNA levels increase in human bronchial epithelial BEAS-2B cells exposed to chrysotile fibers. Finally, both types of asbestos, but not RCF-1, increased nuclear levels of nuclear factor-kappaB (NF-κB), a transcription factor common to increased expression of ICAM-1 and uPA. These data demonstrate that asbestos caused fiber-specific activation of endothelial and pulmonary epithelial cells, resulting in phenotypes capable of facilitating tissue remodeling.”

Another interesting study is called, “Transfection of a manganese-containing superoxide dismutase gene into hamster tracheal epithelial cells ameliorates asbestos-mediated cytotoxicity” by Brooke T. Mossman, Piyawan Surinrut, Bradford T. Brinton, Joanne P. Marsh, Nicholas H. Heintz, Barbara Lindau-Shepard and Jacquelin B. Shaffer – Free Radical Biology and Medicine – Volume 21, Issue 2, 1996, Pages 125-131.  Here is an excerpt: “Abstract – To determine if overexpression of manganese-containing SOD (MnSOD) alters cell sensitivity to asbestos, an expression cassette containing murine MnSOD cDNA was cotransfected with pSV2neo, a plasmid conferring resistance to the antibiotic G418, into a diploid cell line of hamster tracheal epithelial (HTE) cells. Pools of G418-resistant transfectants were characterized by Southern and Northern blot analyses and enzyme activity assays. Although increases in MnSOD gene copies in individual cell pools ranged from approximately 7- to 86-fold in comparison to cells transfected with pSV2neo alone, steady-state levels of MnSOD mRNA were increased only by 1.4-to 2.3-fold. Despite modest increases in MnSOD mRNA, significant elevations in MnSOD enzyme activity were observed in pools of G418-resistant cells. MnSOD-transfected cell lines were more resistant to the cytotoxic effects of crocidolite asbestos using a sensitive colony-forming efficiency (CFE) assay. These data show that MnSOD has a direct role in cell defense against asbestos-induced cytotoxicity, an oxidant-dependent process.”

Another interesting study is called, “A study of the short-term retention and clearance of inhaled asbestos by rats, using U.I.C.C. standard reference samples.” By Middleton AP, Beckett ST, Davis JM. – Inhaled Part. 1975 Sep;4 Pt 1:247-58.  Here is an excerpt: “Abstract – Rats have been dosed over a 6-week period with U.I.C.C. standard reference samples of amosite, crocidolite and chrysotile A, each at three concentrations: 1,5 and 10 mg/m3. Mass concentrations in the exposure chambers were monitored daily. Because the M.R.E. gravimetric sampler was found to undersample some of these dusts at high concentrations, a sampler with a vertical elutriator was developed. Data on other physical parameters of the dust clouds were also obtained and it was found that the fibre number (greater than 5 micron in length) vs. mass correlation varied markedly between asbestos varieties. After dusting, the rats were sacrificed in five batches over a period of 4 months. The lungs of some animals were retained for pathological examination. This did not reveal any fibrosis although large numbers of fibres were visible, mostly within alveolar macrophages. The remaining lungs were analysed for their asbestos contents by a method based upon infrared spectrophotometry. The clearance data confirm earlier published reports that for rats dosed at similar mass concentrations of chrysotile and amphibole, those dosed with chrysotile retain considerably less dust in their lungs. The data also suggest that the retention and clearance of amphibole abestos may be dose related. Some mathematical treatment of the clearance data has been undertaken.”

We all owe a debt of gratitude to these fine researchers.  If you found any of these excerpts interesting, please read them in their entirety.

Monty Wrobleski is the author of this article, for more information please click on the following links:

 

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