Posts Tagged ‘Exposure’

Pleural Thickening and Profusion Resulting From Asbestos Exposure

Pleural Thickening and Profusion Resulting From Asbestos Exposure

Asbestos exposure is a known cause of cancer.  A plethora of research has been done in the past to establish causation.  One interesting study is called, “Asbestos exposure and asbestos-related pleural and parenchymal disease associations with immune imbalance” by Sprince NL, Oliver LC, McLoud TC, Eisen EA, Christiani DC, Ginns LC – Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):822-8. Medical Services Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, Massachusetts.  Here is an excerpt: “Abstract – The study hypothesis was that asbestos exposure and asbestos-related pleural plaques and interstitial disease are associated with (1) immune imbalances favoring helper-inducer T-cell subsets in blood and bronchoalveolar lavage (BAL) and (2) T-lymphocyte accumulation in BAL. One hundred twenty-two asbestos-exposed subsets (AES), including 27 nonsmokers (NS), were evaluated and compared with 10 unexposed normal subjects. Data were collected on medical, smoking, and occupational histories, physical examination, spirometry, lung volumes, single-breath DLCO, chest films read by a “B” reader, and T-lymphocyte characterization in blood and BAL using flow cytometry analysis of monoclonal-antibody-treated cells. On average, AES were 47 yr of age and had 23 yr of asbestos exposure. Fifty-eight (48%) had pleural thickening, and seven (6%) had profusion greater than or equal to 1/0. In blood, asbestos-exposed NS had lower total and percent CD8 and lower total CD3 than did normal subjects. In BAL, asbestos-exposed NS had higher total CD3 than did normal subjects. Among AES, increased asbestos exposure was associated with increased percent CD8 in BAL and decreases in both percent lymphocytes and total CD8 in blood. Increase in CD4/CD8 ratio in BAL were associated with pleural thickening. In those seven with profusion greater than or equal to 1/0, there was increased percent CD4 in blood and decreased percent CD8 in BAL. These results suggest immune imbalance favoring helper-inducer T-cell subsets in association with asbestos exposure systemically and with pleural plaques in BAL.”

A second study is called, “Changing attitudes and opinions regarding asbestos and cancer 1934-1965″ by Enterline PE.  Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261.  Am J Ind Med. 1991;20(5):685-700.  Here is an excerpt: “Literature published in the years 1934-1965 was reviewed to determine attitudes and opinions of scientists as to whether asbestos is a cause of cancer. In Germany, the issue was decided in 1943 when the government decreed that lung cancer, when associated with asbestosis (of any degree), was an occupational disease. In the United States, however, there was no consensus on the issue until 1964. Opinions of scientists over a 22 year period are shown and the contributions of various cultural, social, economic and political factors to these opinions are discussed. A lack of experimental and epidemiological evidence played a major role in delaying a consensus. Other important factors included a rejection of science conducted outside of the U.S. during this period, particularly a rejection of German scientific thought during and after WWII, and a rejection of clinical evidence in favor of epidemiological investigations. Individual writers rarely changed their minds on the subject of asbestos as a cause of cancer.”

If you found any of these studies interesting, please read them in their entirety.  We all owe a great deal of thanks to the people who are researching these important issues.

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The Facts About Asbestos Exposure

The Facts About Asbestos Exposure

Knowing the facts about asbestos exposure will help you to protect yourself and your loved ones. The U.S. and many other governments have compiled fact sheets and created guidelines and laws for handling and reporting asbestos exposure, as well as strict guidelines for asbestos removal and abatement. Being informed about asbestos and the dangers of asbestos exposure can help you avoid becoming a statistic.


Why Asbestos Exposure is a Problem


The danger of asbestos exposure arises from inhaling and swallowing tiny dust particles and fibers. Those particles are released when asbestos is broken up or disturbed in anyway. Once the asbestos fibers have been inhaled or swallowed, they may lodge in the lining around the lungs, heart or abdominal cavity and go unnoticed for decades.


Eventually, though, they cause scarring and cell changes that can become a malignant cancer known as mesothelioma. Even when mesothelioma does not develop, asbestosis and other asbestos related conditions can cause pain, restricted breathing and other difficulties.


How Asbestos Exposure Happens


There are many ways to be exposed to asbestos, but the most common type of asbestos exposure is occupational, or work related. Asbestos was used in the construction industry, the auto industry, on the railroads and in shipyards and in many factories that made items coated with or woven with asbestos.


When the asbestos was broken, moved, sanded, poured or otherwise manipulated, fine particles and dust was released into the air, where it was inhaled and swallowed. Family and household members of people who worked with asbestos were also often exposed to the dust when it was carried home in clothing and hair.


People who lived in the vicinity of asbestos plants may have been exposed to asbestos in the environment. According to the Agency for Toxic Substances and Disease Registry, residents who lived near asbestos plants may have been exposed to asbestos by breathing the air within a few blocks of the plant, playing in waste piles of rock near the factories and moving or handling waste rock from processing plants.


In addition, there is a significant risk of exposure to asbestos in some older buildings where asbestos laced materials were used in construction. These materials are safe as long as they are covered and/or in good condition. However, asbestos may be disturbed during renovations, demolition or when flooring, ceilings and walls become damaged.


How to Protect Yourself from Asbestos Exposure

Although the use of asbestos in new products is now heavily regulated, there are still ways that you might be exposed to asbestos. If your home was built before 1978, for instance, it likely contains many materials that were made with asbestos.


Most of these materials only become a concern when they are disturbed or start to decay. Asbestos exposure can become a significant risk if you are renovating or dealing with the aftermath of a flood, fire or other event that damaged your home. If you’re not certain about materials in your home that may contain asbestos, it’s best to contact your local town offices or health department to find out about having your home evaluated for asbestos and what sort of asbestos abatement regulations apply in your area.


What You Can Do If You Believe You Were Exposed to Asbestos


Mesothelioma affects thousands of people every year. Because its earliest effects are often mistaken for the symptoms of a cold, virus or flu, it’s often not diagnosed until it has progressed beyond the treatable stage.


For that reason, anyone who worked or works in a job with a high risk of asbestos exposure should have regular medical checkups that include lung x-rays, and be especially watchful for respiratory ailments which may be the earliest symptoms of mesothelioma.


In addition, when asbestos exposure combines with smoking, your risk of developing lung cancer increases astronomically. If you were exposed to asbestos in the past and you smoke, quitting now can significantly reduce your chances of developing lung cancer.


Why Asbestos Exposure is a Legal Issue


Asbestos was one of the most widely used industrial minerals through the early to mid 1970s. The companies that mined, distributed and used asbestos were very aware of the danger that asbestos posed to their workers.


Instead of warning them and providing for safer handling, the industry deliberately hid those dangers from the public, their workers and the government. In doing so, they callously exposed hundreds of thousands of workers and their families to a deadly carcinogen.


Because these companies were aware of the dangers of asbestos and did nothing to warn or protect their workers intentionally, they may be legally liable for compensating people who became ill because of asbestos and their families.


If you believe that you or a family member became ill because of asbestos exposure, a law firm experienced in handling asbestos-related cases can evaluate your claim and help you get the compensation you deserve for your loss.

Tim Dillard is a marketing executive who has worked with some of the largest law firms in America. Dillard is currently the president of Dillard Local Branding (http://www.dlbllc.com), a Houston-based web design, Internet marketing and search engine marketing firm.


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South Florida Miles for Meso 8K Returns to Raise Awareness and Funding for Rare Cancer Caused by Asbestos Exposure

South Florida Miles for Meso 8K Returns to Raise Awareness and Funding for Rare Cancer Caused by Asbestos Exposure
Sokolove Law, a leading provider of legal services and the nation’s most trusted mesothelioma law firm, is proudly serving as a presenting sponsor of the 2011 South Florida Miles for Meso road race. Now in its third year, the South Florida Miles for Meso event will feature an 8K road race and a 4K tribute walk to create mesothelioma awareness and raise money to support research for a cure. All …
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Mesothelioma, Lung Cancer, Asbestos Exposure and Other Tragedies You May Ignore (Reading About)

Mesothelioma, Lung Cancer, Asbestos Exposure and Other Tragedies You May Ignore (Reading About)

Lung Cancer, like all forms of cancer, is a terrible disease. It leaves its victims in so much pain and throws away their quality of life. It is caused through a variety of ways, the most popular one being tobacco smoking. Not surprising, considering the vast amount of people across the world who smoke. Less commonly known causes include exposure to petroleum gases you tend to inhale when at a filling station, exposure to asbestos and consistent exposure and/or inhalation of smog like that of being trapped in a gridlock rush hour.

A very rare form of lung tumors is mesothelioma. It affects a handful of people, for example in the United States, but its incidence rate is significantly growing, i.e. a lot more people than previously are being diagnosed with the malignant tumor. The cancer to a large degree can be caused by unprotected & prolonged exposure to asbestos. An outrageously high amount of the brave HERO rescue workers who endangered their lives to fight the madness of 9-11 as it unfolded in New York, developed mesothelioma and other (somewhat) preventable types of lung cancer. A lot of the SAINT rescue workers, beloved by their families, friends communities and country, sadly already passed away in the near decade since the atrocity was cowardly committed by terrorists.

There is no known cure for it to date. It is a horrible monster befalls unassuming, everyday people and shatters entire families. Many families grieving the loss of their loved one(s) are left to pick up the pieces from the havoc wrecked by the nightmare. Since mesothelioma is so much of a rare disease, it’s very difficult for those left behind to come to terms with the realities of it, i.e. why it had to happen; ‘If it’s so rare, why did it have to happen to me/us etc?’ I have had the chilling experience of witnessing a lady interact with group members of a mesothelioma forum, first asking everybody to keep her uncle in their prayers as he’s battling mesothelioma, then returning a few days after to announce that he had passed away. This was very disturbing, especially as I was amongst the people who sent her goodwill messages to console her when she first made the announcement.

Due to the fact that mesothelioma is more often than not developed through the exposure to asbestos, it can unfortunately present itself in a number of (potentially) hazardous situations, if proper care is not taken to observe and inspect the environment at home, school, work or many other places. In the United States, for example, there have been a growing number of incidents of official/authoritative negligence on part of school boards, employers, government ministries etc to ensure that respectively children, artisans, civil servants etc are protected from (potentially) dangerous exposure to asbestos by protective means or even denial access.

The Mesothelioma & Asbestos Awareness Center reported “Those who’ve studied the potential hazard of asbestos caused by the collapse of the World Trade Center estimate that more than 110,000 people may have suffered serious exposure including 80,000 tower workers, 30,000 local residents, and 4,000 first responders. Deborah Reeve was the first 9/11 emergency responder to die of mesothelioma. Doctors agree that her exposure to asbestos was a result of her days spent working at the recovery site.”

By and large, many organisations and institutions tend to flout regulations and health & safety procedures stipulated by law or stick to them in a completely unacceptable manner. Thereby, people are put at risk of contracting the disease and/or those who have already been diagnosed with mesothelioma are left uncared for, unattended by institutions and unable to get the professional and highly competent support and assistance they require, in a legal capacity.

The track record of legal experts in the fields of lung cancer and mesothelioma has been impressive; incredible amounts of compensation have been paid out to families of mesothelioma sufferers, in support of their plight to fight the cancer and address the gross maltreatment and inequality they have experienced at the hands of their academic or vocational superiors. It is therefore advised to quickly seek the help of a trusted legal expert, with a proven track record on lung cancer and mesothelioma litigation cases to best address the legal needs in the way it is deserved to have it treated.

Under no circumstances does this article intend in any way to discredit the United States of America. The content has been attempted to be portrayed as factually as possible. Any subliminal mocking of any nature that could possibly be inferred from it, is completely unintentional.

References:

The Mesothelioma & Asbestos Awareness Center

http://www.maacenter.org/jobsites/WTC/asbestos.ph

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The Lethal Cancer Known as Mesothelioma and Chronic Exposure to Asbestos

The Lethal Cancer Known as Mesothelioma and Chronic Exposure to Asbestos

Mesothelioma is a lethal cancer that can attack the membranes surrounding the heart, lung, and stomach.  One interesting article that examines asbestos exposure in vitro is called, “Human Alveolar Macrophage Cytokine Release in Response to in Vitro and in Vivo Asbestos Exposure” by Raymond C. Perkins, Ronald K. Scheule1, Raymond Hamilton, Glen Gomes, Gary Freidman and Andrij Holian – Division of Pulmonary and Critical Care Medicine, Departments of Internal Medicine and Pharmacology, University of Texas Medical School at Houston and Environmental and Occupational Research Center, Houston, TX.  Experimental Lung Research – 1993, Vol. 19, No. 1, Pages 55-65 – Here is an excerpt: “The lung macrophage is proposed to be involved in the development of asbestos-induced pulmonary fibrosis. Knowledge of the effects of long-term asbestos exposure on lung macrophage cytokine release should better define the role of the macrophage in fibrogenesis.

This study examines the effects of acute in vitro asbestos exposure and chronic in vivo asbestos exposure on human alveolar macrophage cytokine release. As indicators of asbestos-induced macrophage activation, the cellular release of IL-1β, TNF-α, IL-6, GM-CSF, and PGE2 was mesaured during a 24-h in vitro culture. Alveolar macrophages from normal volunteers were cultured in vitro with chrysotile asbestos. Of the factors measured, only TNF-α was elevated in response to asbestos exposure. Alveolar macrophages from asbestos-exposed individuals were placed into one of two groups based on their exposure history. These two groups were matched for age, smoking history, and diagnosis; none met the criteria for asbestosis. Cells isolated from subjects that had been exposed to asbestos for more than 10 years secreted enhanced basal amounts of IL-10, TNF-α, IL-6, and PGE2, while those who had been exposed for less than 10 years did not. The results indicate that while asbestos had minimal acute effects on cytokine production by the human alveolar macrophage, intense, chronic exposure to asbestos leads to the enhanced basal release of significant amounts of several cytokines that have activity for the fibroblast, even in the absence of overt fibrosis.”

Another interesting article by Huuskonen MS, Koskinen K, Tossavainen A, Karjalainen A, Rinne JP, Rantanen J. – Finnish Institute of Occupational Health Asbestos Program 1987-1992.  Am J Ind Med. 1995 Jul;28(1):123-42.  Here is an excerpt: “Abstract – In 1987-1992, the Finnish Institute of Occupational Health (FIOH) implemented a nationwide asbestos program aimed at preventing asbestos-related risks in good cooperation with governmental authorities, industry, trade unions, the health care and insurance systems, and mass media. The goals were to minimize all exposure to asbestos, identify people exposed at work, and improve the diagnostics of asbestos diseases, especially cancers. The program entailed several concrete actions and extensive dissemination of information, training, services, and scientific research. As proposed by the State Asbestos Committee, new use of asbestos products was banned and strict regulations were applied to renovation and inspection of old buildings. The screening study of asbestos-induced diseases included 18,943 current and retired workers from house building, shipyard, and asbestos industries. Pleural and parenchymal changes were found in 4,133 persons (22%), who were referred to further clinical examinations as suspected cases of an occupational disease. It was estimated that past exposure of asbestos among the Finnish population of 5 million causes > 150 mesotheliomas and lung cancers annually, totalling > 2,000 asbestos-induced cancer deaths by the year 2010. Although several major control actions were made or started during the program, the bulk of the preventive work still lies ahead.”

A third interesting article is called, “Dose-responsive increases in pulmonary fibrosis after inhalation of asbestos” by TR Quinlan, JP Marsh, YM Janssen, KO Leslie, D Hemenway, P Vacek and BT Mossman – Department of Pathology, University of Vermont, Burlington 05405.  Am. J. Respir. Crit. Care Med., Vol 150, No. 1, 07 1994, 200-206.   Here is an excerpt: “We focused here on steady-state mRNA levels of genes involved in antioxidant defense, i.e., manganese superoxide dismutase and copper- zinc superoxide dismutase, and in cell proliferation, i.e., ornithine decarboxylase, c-jun, and glyceraldehyde-3-phosphate-dehydrogenase in whole-lung homogenates from Fischer 344 rats at 3 h to 20 d after exposure to crocridolite asbestos. Changes in gene expression were correlated with histopathologic findings, total and differential cell counts in bronchoalveolar lavage, and levels of hydroxyproline in lung. Dosage-dependent increases in mRNA levels of antioxidant enzymes and proliferation-related genes were observed. Differential cell counts revealed a dose-related infiltration of neutrophils that preceded elevations in gene expression. Neutrophil infiltration into lung and focal lesions of fibrosis as well as increased levels of hydroxyproline were observed only at high concentrations of asbestos. These results indicate that high airborne concentrations of asbestos cause molecular changes in lung that may be related to antioxidant defense and the triggering of cell proliferation, a feature of asbestosis and lung cancer.”

If you found any of these excerpts interesting, please read the studies in their entirety.  We all owe a great debt to these fine researchers.

Monty Wrobleski is the author of this article.  For more information please click on the following links  Mesothelioma Lawyer,

Mesothelioma Lawsuit Settlements,

Asbestos Exposure


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