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Pleural Thickening and Profusion Resulting From Asbestos Exposure

Pleural Thickening and Profusion Resulting From Asbestos Exposure

Asbestos exposure is a known cause of cancer.  A plethora of research has been done in the past to establish causation.  One interesting study is called, “Asbestos exposure and asbestos-related pleural and parenchymal disease associations with immune imbalance” by Sprince NL, Oliver LC, McLoud TC, Eisen EA, Christiani DC, Ginns LC – Am Rev Respir Dis. 1991 Apr;143(4 Pt 1):822-8. Medical Services Pulmonary and Critical Care Unit, Massachusetts General Hospital, Boston, Massachusetts.  Here is an excerpt: “Abstract – The study hypothesis was that asbestos exposure and asbestos-related pleural plaques and interstitial disease are associated with (1) immune imbalances favoring helper-inducer T-cell subsets in blood and bronchoalveolar lavage (BAL) and (2) T-lymphocyte accumulation in BAL. One hundred twenty-two asbestos-exposed subsets (AES), including 27 nonsmokers (NS), were evaluated and compared with 10 unexposed normal subjects. Data were collected on medical, smoking, and occupational histories, physical examination, spirometry, lung volumes, single-breath DLCO, chest films read by a “B” reader, and T-lymphocyte characterization in blood and BAL using flow cytometry analysis of monoclonal-antibody-treated cells. On average, AES were 47 yr of age and had 23 yr of asbestos exposure. Fifty-eight (48%) had pleural thickening, and seven (6%) had profusion greater than or equal to 1/0. In blood, asbestos-exposed NS had lower total and percent CD8 and lower total CD3 than did normal subjects. In BAL, asbestos-exposed NS had higher total CD3 than did normal subjects. Among AES, increased asbestos exposure was associated with increased percent CD8 in BAL and decreases in both percent lymphocytes and total CD8 in blood. Increase in CD4/CD8 ratio in BAL were associated with pleural thickening. In those seven with profusion greater than or equal to 1/0, there was increased percent CD4 in blood and decreased percent CD8 in BAL. These results suggest immune imbalance favoring helper-inducer T-cell subsets in association with asbestos exposure systemically and with pleural plaques in BAL.”

A second study is called, “Changing attitudes and opinions regarding asbestos and cancer 1934-1965″ by Enterline PE.  Department of Biostatistics, Graduate School of Public Health, University of Pittsburgh, PA 15261.  Am J Ind Med. 1991;20(5):685-700.  Here is an excerpt: “Literature published in the years 1934-1965 was reviewed to determine attitudes and opinions of scientists as to whether asbestos is a cause of cancer. In Germany, the issue was decided in 1943 when the government decreed that lung cancer, when associated with asbestosis (of any degree), was an occupational disease. In the United States, however, there was no consensus on the issue until 1964. Opinions of scientists over a 22 year period are shown and the contributions of various cultural, social, economic and political factors to these opinions are discussed. A lack of experimental and epidemiological evidence played a major role in delaying a consensus. Other important factors included a rejection of science conducted outside of the U.S. during this period, particularly a rejection of German scientific thought during and after WWII, and a rejection of clinical evidence in favor of epidemiological investigations. Individual writers rarely changed their minds on the subject of asbestos as a cause of cancer.”

If you found any of these studies interesting, please read them in their entirety.  We all owe a great deal of thanks to the people who are researching these important issues.

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Mesothelioma Support From A Good Attorney Can Lead To Compensation And Justice

Mesothelioma Support From A Good Attorney Can Lead To Compensation And Justice

Fear, anger, and sadness are powerful emotions which can all be felt after being diagnosed with the deadly cancer known as mesothelioma, and it can be said that for many of those who are diagnosed with mesothelioma, the suffering experienced can be blamed on the negligence of someone else; since this is the case, mesothelioma support from an experienced attorney should be sought as appropriate compensation and justice could result from legal action.

Although advanced treatment for mesothelioma has led to an extension of life for a number of those diagnosed with this serious illness, there is unfortunately still no cure, and this fact coupled with the physical and financial trauma which may be associated with the illness can leave an individual and his or her family feeling completely overwhelmed. Without a doubt, if all of this pain and anguish was caused by being negligently exposed to asbestos or perhaps another mesothelioma-causing material, then appropriate compensation should be paid to the victim or victims of the disease. However, it should be noted that if appropriate compensation is to be paid, the services of an experienced mesothelioma attorney will undoubtedly be needed.

Has mesothelioma caused you and/or your family to suffer immensely? Do you have a belief that your suffering was the result of someone else’s negligence, such as a former employer? If you suspect that your or your loved one’s mesothelioma was the result of being exposed to asbestos or other fibrous material in a manner which was negligent, then there is no question that you should get in touch with an experienced attorney who can help! With the assistance of an attorney, it can be found whether or not solid grounds for seeking appropriate compensation exist; if the attorney does feel that legal action should be taken, then the mesothelioma litigation process can begin so that you and your family can have a chance at gaining the most appropriate compensation possible for the tremendous pain inflicted.

Legal help is available! If you contact the Law Offices of Chandler, Mathis & Zivley, PC, you’ll be able to receive a free legal consultation from an experienced attorney who will provide you with nothing less than sound legal counsel! Be sure to find the legal assistance your family deserves today, or if you would like to learn more about mesothelioma support, then you can simply continue browsing through the rest of the Mesothelioma Information and Support Center website.

http://mesothelioma-attorney-info.com/mesothelioma-support.php
If you or someone you know has mesothelioma, then there’s a very good chance that it was caused from asbestos exposure. With help from an experienced mesothelioma attorney, you’ll have an excellent chance of receiving the proper compensation for your mesothelioma, if indeed, it was caused by the negligence of someone else. Our team of skilled attorney


Article from articlesbase.com

Related Mesothelioma Causes Articles

Cancer Incidence Among Workers Resulting from Exposure to Asbestos Dust and Fibers

Cancer Incidence Among Workers Resulting from Exposure to Asbestos Dust and Fibers

Some occupations are considered more dangerous when it comes to asbestos exposure.  For example, people working as pipefitters, plumbers, and electricians suffer from an inordinate rate of mesothelioma disease.  This has been the subject of a great deal of research.  One interesting study is called, “Asbestos exposure, smoking habits, and cancer incidence among production and maintenance workers in an electrochemical plant” by Bjorn Hilt, MD, Sverre Langad, MD, MSc, Aage Andersen, Jan Rosenberg, MD – Department of Occupational Medicine, Telemark Sentralsjukehus, Porsgrunn, Norway, Cancer Registry of Norway, Montebello, Oslo, Norway, Health Department, Norsk Hydro A.S., Porsgrunn Fabrikker, Porsgrunn, Norway – American Journal of Industrial Medicine – Volume 8 Issue 6, Pages 565 – 577.  Here is an excerpt: “Abstract – The incidence of cancer was studied in a cohort of 287 men who were exposed to asbestos at a nitric acid production plant from 1928 onwards. During the observation period from 1953 through 1980 all cancer cases among the cohort members were identified in The Cancer Registry. For the whole cohort 42 cases of cancer were observed versus 30.6 expected. The figures for cancer of the lungs and pleura combined were 17 observed versus 3.7 expected. The corresponding figures for a heavily exposed subcohort were 11 observed and 1.2 expected. In that group there was also an increased incidence of colon cancer with 3 cases observed against 0.8 cases expected. Within the whole cohort four cases of pleural and one case of peritoneal malignant mesothelioma were found. There was also an increased incidence of malignant melanoma of the skin with 3 cases observed against 0.6 expected. For cancer cases that were registered as of unknown origin there were 7 cases observed and 1.4 expected. There was no increased rate ratio for cancer at any site before 20 years after the first asbestos exposure. The smoking habits of all cohort members were recorded and the relative rates for lung cancer were calculated in relation to smoking habits. In common with previous studies the results indicate a multiplicative model for the interaction between asbestos exposure and smoking in regard to lung cancer risk.”

Another interesting study is called, “Tests for effect of asbestos on benzo(a)pyrene carcinogenesis in the respiratory tract” by Miller, L.; Smith, W.E.; Berliner, S.W. 
Publication Date 1965 Jan 01 – Ann. N.Y. Acad. Sci.; (United States); Journal Volume: 132.  Here is an excerpt: “Hamsters were given 25 intratracheal injections of 0.5 mg benzopyrene (BaP) in Tween-60 with or without 0.25 mg chrysotile (Chrys) asbestos. 173 to 214 days after start of injections, 4 tumors in 3/5 surviving animals subjected to BaP alone were found whereas 7/7 (15 total) were found in those given BaP plus Chrys. Three of these were larger than 3 mm. Animals given Chrys or Tween alone or control animals had no tumors. 16 injections of 0.5 mg BaP in Tween-60 with or without 2.5 mg amosite (AM) asbestos were given to hamsters. 29% of group given BaP and 26% of group given BaP plus AM had tracheobronchial tumors when sacrificed at day 240. One form of asbestos synergistically increased carcinogenic activity of BaP. Yield of tumors decreased with time after discontinuation of injections suggesting reversible action.”

Another interesting study is called, “DNA single strand breaks induced by asbestos fibers in human pleural mesothelial cells in vitro” – Environmental and Molecular Mutagenesis
Volume 33 Issue 2, Pages 153 – 160.  Here is an excerpt: “Abstract – The mechanisms of the cellular effects and DNA damage caused by asbestos fibers in human mesothelial cells are not well understood. We exposed transformed human pleural mesothelial cells to 1-4 g/cm2 crocidolite and to 10-100 ng/ml tumor necrosis factor alpha for up to 48 hr and studied the induction of DNA damage using the Comet assay. As a positive control, 100 M H2O2 was used. The DNA single strand breaks were assessed as the mean tail moments and as distributions of the tail DNA in the cell. The Comet assay showed significant but reversible increases in the mean tail moments, but not in the distribution of Comet tails in the histograms in cells exposed to 1 g/cm2 crocidolite for 6 hr. At higher concentrations of asbestos fibers all the indices in the Comet assay showed significant and irreversible change. All the doses of TNF- caused marginal increase in the mean tail moments. The mean tail moments were highest in the cells with concurrent treatment to TNF- and crocidolite. In the cells pretreated with inhibitors of antioxidant enzymes (aminotriazole for catalase and buthionine sulfoximine for -glutamylcysteine synthetase) asbestos fibers slightly increased oxidant-related fluorescence of dichlorofluorescein (DCFH) but did not cause any further increases in the mean tail moments. This study shows that asbestos fibers cause DNA single strand breaks in human mesothelial cells. Since the inhibition of antioxidant enzymes did not have an effect on the DNA damage caused by the fibers, other mechanisms than free radicals seem to be involved in the induction of DNA damage by mineral fibers.”

If you found any of these excerpts interesting, please read the studies in their entirety. 

Monty Wrobleski is the author of this article.  For more information please click on the following links Mesothelioma Attorney Illinois,

Chicago Mesothelioma Lawyers,

Texas Mesothelioma Attorney


Article from articlesbase.com

An Acceptable Mesothelioma Settlement Is Possible With Help From An Experienced Attorney

An Acceptable Mesothelioma Settlement Is Possible With Help From An Experienced Attorney

Comforting someone who has developed mesothelioma can be a difficult task. Indeed, this rare type of cancer can cause deep emotional pain, and this emotional strife mixed with the physical realities of the disease can be overwhelming for the individual suffering from mesothelioma. However, if someone else’s negligence is to blame for all of this pain and suffering, then some easing to the suffering can be experienced through a suitable mesothelioma settlement.

Litigation is never an easy thing to engage in, and although no family really wants to go through the stress of the litigation process, in many cases, taking legal action is the only way in which appropriate compensation can be gained for the immense suffering sustained. It can be said that in a number of mesothelioma cases, litigation may be the only way in which those suffering from the mesothelioma and their families can receive justice for the misery being experienced; however, in order to have the best chance at receiving the most appropriate compensation and justice possible, the help of a mesothelioma attorney will no doubt be needed.

Are you or a loved one suffering from mesothelioma which you suspect was caused by someone else’s negligence? No matter how you believe you or your loved one was exposed to asbestos or other mesothelioma-causing material, if someone else’s negligence allowed for the mesothelioma to develop, then appropriate compensation for all of the physical, emotional, and financial suffering can be gained. However, proving that someone else is responsible for tremendous suffering may be a big challenge, especially in the case where mesothelioma has developed as it’s the case the mesothelioma symptoms and a diagnosis may not occur until many years and even perhaps decades after first being exposed to asbestos or other fibrous material. Needless to say, the next step that you should take is to contact a qualified attorney as a legal professional will be able to help uncover the truth regarding your or your loved one’s suffering, and if someone else is responsible for the suffering sustained, then your attorney will surely do everything possible so that appropriate compensation can be gained.

Gain the chance at receiving justice for you or your loved one! Get in touch with the Law Offices of Chandler, Mathis & Zivley, PC today and speak to an attorney who can help. Also be sure to continue browsing through the rest of the Mesothelioma Information and Support Center website for more information regarding mesothelioma settlement.

http://mesothelioma-attorney-info.com/mesothelioma-settlement.php
If you or someone you know has mesothelioma, then there’s a very good chance that it was caused from asbestos exposure. With help from an experienced mesothelioma attorney, you’ll have an excellent chance of receiving the proper compensation for your mesothelioma, if indeed, it was caused by the negligence of someone else. Our team of skilled attorney


Article from articlesbase.com

Lastest “lung Cancer From Asbestos” News

Poison hugs blamed for two women’s asbestos poisoning deaths
A MUM of two who got lung cancer from asbestos dust on her grandad’s work clothes died last week.
Read more on Daily Mirror

Who is at risk from mesothelioma cancer?

Who is at risk from mesothelioma cancer?

Mesothelioma is a deadly cancer which is fairly rare although in the last few decades the number of people who have died from it have dramatically increased.  Mesothelioma is caused by exposure to asbestos without sufficient protection.  When a person is exposed to asbestos, he or she inhales tiny asbestos fibres which are suspended in the air.  These fibres pass into the respiratory system and end up becoming lodged in the lungs.  An accumulation of asbestos fibers in the lining of the lungs like this can cause nearby cells to deform and eventually leads to what is known as pleural mesothelioma.  Accumulation of asbestos fibers in the peritoneum (lining of the abdomen) can lead to peritoneal mesothelioma and build up of fibres around the tissue of the heart can cause pericardial mesothelioma.  Asbestos fibers reach these places over time or because they have been transported there by the lymphatic system.

Mesothelioma cancer has a very large latency period (time between getting the cancer and feeling the symptoms of it).  This period is usually between 30 – 50 years and so a person who bears mesothelioma is unlikely to know that they have got it.  This is why mesothelioma is so hard to diagnose in its early stages because it shows no symptoms and the few symptoms that it does show such as wheezing and shortness of breath are typical of far more common diseases such as pneumonia.  The likelihood of being cured depends largely on how early and how aggressively the cancer is treated.  If it is treated when it has fully developed and matured then it is extremely difficult to cure.

In this way, those at risk are those who have worked amongst asbestos.  Construction workers, asbestos manufacturers or those who have lived within a mile of an asbestos factory are the people who have the largest contact with asbestos.  Those who are in contact with these people are also at risk because asbestos fibres can stick to clothes and hair.  The majority of people who are discovering that they have mesothelioma are elderly men of about 60 – 70.  This was the generation which worked with asbestos a lot without sufficient protection.  Many of these men are now lodging multi million dollar lawsuits against the companies who exposed them to the dangers of asbestos.

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