Posts Tagged ‘Malignant’

Evaluating Benign and Malignant Lung and Pleural Masses in Asbestosis and Mesothelioma

Evaluating Benign and Malignant Lung and Pleural Masses in Asbestosis and Mesothelioma

Exposure to asbestos in the workplace is the most common cause of Mesothelioma disease.  Continued research is necessary if we are ever to find a cure.  One interesting study is called, “Exposure to Asbestos and Human Disease.” By Becklake, MR – New England Journal of Medicine Vol. 306, no. 24, pp. 1480-1482. 1982.  Here is an excerpt: “During the past two decades, ill health resulting from exposure to asbestos has been the subject of extensive observation and research — probably more intensive than research on any other environmental agent. In the most direct target organ, the lung, in its pleural coverings, there is a wide spectrum of response after exposure; not only acute and chronic inflammatory diseases but also cancer of these organs may occur. Research has been stimulated by the belief that the more complete our understanding of the mechanisms of pathogenesis, the better will be the ability to control the continued use of this mineral in today’s complex technologic world.”

Another interesting study is called, “Analysis of amphibole asbestos in chrysotile and other minerals.” By Addison, J, Davies, LST – Annals of Occupational Hygiene [ANN. OCCUP. HYG.]. Vol. 34, no. 2, pp. 159-175. 1990.  Here is an excerpt: “Chrysotile asbestos and many other mineral raw materials contain amphibole minerals which may be asbestiform. There is currently no analytical method which will detect the presence of amphibole at sufficiently low limits to preclude the possibility of inadvertent exposure of persons handling these materials to hazardous airborne fibre concentrations. A method of chemical digestion of chrysotiles has been tested with regard to the determination of their tremolite contaminant content and this has been applied to a range of chrysotile and other minerals. The method improves the sensitivity of the amphibole analysis at least 10-fold giving detection limits of 0.01-0.05% in chrysotile by X-ray diffractometry.”

Another interesting study is called, “Computed tomography in the diagnosis of asbestos-related thoracic disease” by Gamsu, Gordon MD; Aberle, Denise R. MD; Lynch, David MD, BCh – Journal of Thoracic Imaging – January 1989 – Volume 4 – Issue 1.  Here is an excerpt: “Abstract – High-resolution computed tomography (HRCT) has improved the radiologist’s ability to detect and potentially quantify the abnormalities of asbestos exposure. It has proved to be more sensitive than chest radiography for detecting pleural plaques and for discriminating between pleural fibrosis and extrapleural fat. HRCT is also more sensitive than chest radiography or conventional CT for detecting parenchymal abnormalities in asbestos-exposed persons. The HRCT findings that correlate with other parameters of asbestosis include (1) septal and centrilobular thickening, (2) parenchymal fibrous bands, (3) honeycomb patterns, (4) subpleural density persisting in the prone position, and (5) subpleural curvilinear lines that persist in the prone position. CT has an important role in evaluating benign and malignant lung and pleural masses in asbestosis.”

Another study is called, “Effect of Long-Term Removal of Iron from Asbestos by Desferrioxamine B on Subsequent Mobilization by Other Chelators and Induction of DNA Single-Strand Breaks” by Chao C. C. and Aust A. E. – Archives of Biochemistry and Biophysics – Volume 308, Issue 1, January 1994, Pages 64-69.  Here is an excerpt: “
Abstract – The long-term removal of iron from crocidolite or amosite by desferrioxamine B (DF) at pH 7.5 or 5.0 was studied. Crocidolite or amosite (1 mg/ml) was suspended in 50 mM NaCl at pH 7.5 or 5.0 with the addition of 1 mM DF for up to 90 days. Although the rate of iron mobilization decreased with time, iron was continuously mobilized from both forms of asbestos at pH 5.0 or 7.5. The amount of iron mobilized from crocidolite was at least twice that mobilized from amosite at either pH. Iron was mobilized more rapidly from crocidolite at pH 5.0 than at 7.5 for the first 15 days, but at later times the amount being mobilized at pH 7.5 became equal to or slightly greater than that at 5.0. For amosite, the mobilization at pH 5.0 was always greater than that at pH 7.5. Next, the effect of iron removal from asbestos by DF on subsequent iron mobilization by a second chelator (EDTA or citrate) and on induction of DNA single-strand breaks (SSBs) was studied. Asbestos, treated for up to 15 days with DF at pH 7.5, was washed to remove ferrioxamine and excess DF, then incubated with EDTA or citrate (1 mM). The rates of iron mobilization from both forms of asbestos by a second chelator decreased as more and more iron was removed by DF. Induction of DNA SSBs also decreased, reflecting the unavailability of iron to catalyze the damage. The results suggest three things. First, if long-term mobilization of iron from asbestos occurs in vivo as has been observed in vitro, it may play a role in the long-term biological effects of asbestos. Second, more rapid mobilization of iron from asbestos fibers may occur when the fibers are phagocytized by cells and maintained in phagosomes where the pH is 4.0-5.0. Third, treatment of asbestos by iron chelators, such as DF, prior to exposure to cultured cells or whole animals, may reduce the biological effects of asbestos resulting from iron, but may not completely eliminate them.”

We all owe a debt of gratitude to these fine researchers for their hard work and dedication.  If you found any of these excerpts interesting, please read the studies in their entirety.

 

Monty Wrobleski is the author of this article, for more information please visit the following links

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Asbestos Exposure, Malignant Lung Cancer – California Lawyer

kazanvideo.com Asbestos exposure can cause malignant Lung Cancer and other diseases in the California area. These diseases cause victims and their families pain, suffering, and medical expenses. If you or a loved one has been exposed to Asbestos, or is at risk for malignant lung cancer or Mesothelioma, we can help. Find the information you need at our website, or call today 877.622.5246 for a no cost evaluation.
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malignant mesothelioma

For more details click here : www.mesotheliomalifeexpectancysite.com to find out more about pleural mesothelioma
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Asbestos lung mesothelioma – Diagnosis of malignant mesothelioma

Asbestos lung mesothelioma – Diagnosis of malignant mesothelioma

The main form of mesothelioma is the malignant form. Known as malignant mesothelioma, the primary causal factor is asbestos infection. According to the U. S. National Cancer Institute, malignant mesothelioma is a disease in which malignant) cells are found cancer of the heart (in-lining of the SAC chest (pleura), the lining of the abdominal cavity (peritoneum) or the lining around (pericardium). “

Mesothelioma can be assignedinto three types – pleural mesothelioma, peritoneal mesothelioma and pericardial mesothelioma. Pleural mesothelioma refers to a cancer of the lining of the lung (pleura), peritoneal mesothelioma refers to a cancer of the abdominal cavity (peritoneum) lining, and pericardial mesothelioma is a cancer that occurs in the lining of the pericardium (surrounds the heart) . The subtypes of mesothelioma are three basic types, veryaggressive and less aggressive, and one of the two extremes.

http://www.asbestoslungmesotheliomaaa.goodarticlesite.com/diagnosis-of-malignant-mesothelioma/

malignant mesothelioma can be diagnosed with imaging procedures are different. These imaging techniques allow doctors to assess mesothelioma. Once mesothelioma is suspected, patients are advised to undergo more tests, like X-rays, computed tomography (CT) Magnetic Resonance Imaging (MRI) and positron emission tomography (PET ) imaging. Your doctor may also like to takespecial tests such as mesothelioma, thoracoscopy, peritoneoscopy and biopsy.

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Learning on the stage of mesothelioma is critical that doctors will decide, it helps in planning treatment. If the cancer is confined to the pleura, is located as mesothelioma. If the cancer spreads beyond the breast and other body parts like lungs, abdominal cavity, lymph nodes and chest wall, mesothelioma in an advancedStage.

The often used and the oldest system for determining stages of mesothelioma is the Butchart System. The Butchart System is the extent of available primary tumor in a patient. This system is divided into four stages of mesothelioma. The TNM system, an advanced slightly Butchart staging system determined by variables in the tumor mass and spread, lymph node involvement and metastasis. However, the final system known as theBrigham System, where productioN

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Malignant Mesothelioma Information

Malignant Mesothelioma Information

Malignant mesothelioma is a type of cancer that is quite rare; it affects only the thin wall of cells that line the internal organs and structures. This lining is called the mesothelium and malignant mesothelioma can manifest itself in three main ways. It can be pleural which affects the lungs, peritoneal which affects the abdominal cavity wall and pericardial which affects the lining in the heart. Experts believe that there is only one way to contract malignant mesothelioma and that is through exposure to asbestos.

Asbestos is a naturally occurring mineral that is highly toxic to humans yet was once used in abundance in the building and construction trades. It was used as it has a very high tolerance of heat and it is remarkably strong, it was also very cheap. It is made of fibres which are microscopic and can be airborne when ceilings covered with asbestos crack or when it is otherwise exposed to the air. When fibres of asbestos get inside the body they cannot be broken down or expelled and this will result in serious scarring of the mesothelioma and inflammation. Once this scarring occurs it is only a matter of time before malignant mesothelioma takes hold in one of its various forms.

Symptoms of malignant mesothelioma can initially be quite hard to spot as they can be quite unnoticeable. As a result they can be passed off as being day to day illnesses and this can cause even more problems as this delay gives malignant mesothelioma even more time to take hold of a person. It has been known for people with malignant mesothelioma to live with their symptoms for up to six months before they seek medical help with them. Symptoms of the various forms of malignant mesothelioma can include – shortness of breath, weight loss, nausea, vomiting, persistent coughing with or without blood in it, abdominal pains, stomach pains, chest pains, pain in the lower back and in some cases swelling of the face and arms and a loss of sensory capabilities. As these symptoms are so wide ranging and often seemingly unconnected it is no wonder that it can be difficult to obtain a correct diagnosis. Experts now recommend that anyone who has had prior exposure to asbestos at some point in their lives gets checked out for malignant mesothelioma even if they feel fit and well. Doing this could vastly extend a person’s life who could go on to be diagnosed with malignant mesothelioma.

Treatment for malignant mesothelioma can vary and surgery should only be an option if the disease is diagnosed in the very early stages. Otherwise it is more common for a person to undergo chemotherapy or radiotherapy to attempt to control the malignant mesothelioma. Although there is no known cure for malignant mesothelioma it can be controlled for some time if it is caught in time. Otherwise the outlook is not particularly positive and the best that many people with malignant mesothelioma can hope for is to be able to manage their symptoms and pain with painkillers and other medication.

Looking for information about Mesothelioma? Our website provides many useful information including

mesothelioma symptoms, mesothelioma treatments and mesothelioma stages. The site also provided details information about different type of mesothelioma: Malignant Mesothelioma, Pleural Mesothelioma, Pericardial mesothelioma and Peritoneal mesothelioma


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Review on malignant mesothelioma, asbesots and mesothelioma

Review on malignant mesothelioma, asbesots and mesothelioma

Malignant mesothelioma is an uncommon kind of cancer in which fatal cancer cells enter the protective lining of the heart (pericardium), stomach (abdomen) and chest (pleura) causing a disease that in most cases is not curable. The National Cancer Institute has to say that predominantly in cases diagnosed with malignant mesothelioma, individuals have either been subject to asbestos exposure at a work place or someplace else that they spent enough time to end up inhaling asbestos fibers in large quantities. Asbestos exposure does not necessarily lead to cancerous diseases such as in the case of asbestosis but again there are high probabilities that it might give rise to a cancerous disease such as mesothelioma. The disease is often associated with a long latency period which is why workers who got affected during the 40s and 50s are getting diagnosed with mesothelioma only now, decades later.

Asbestos has been declared to be a human carcinogen by many reputed organizations such as the World Health Organization, the Department of Health and Human Services and the Environmental Protection Agency. It has been established case after case that the inhaling of asbestos causes cancer or at least increases the chances of causing cancer in an individual. Asbestos does not only cause lung cancer but also thickening of the pleura. In recent years it has been definitely established that mesothelioma stems from asbestos exposure in most cases.

The relationship between asbestos and lung cancer has now been more or less established. Lung cancer in individuals who have access to asbestos occurs at a younger age than most other people who suffer from cancer and the asbestos exposed individuals experience the cancer in the lower regions of the lungs. This is known as the synergistic effect between asbestos exposure and smoking cigarettes and if the person is a smoker then the chances of contracting lung cancer are immensely high. Thus if you have been subject to asbestos exposure the least you can do to increase your chances of improving health conditions is to quit smoking. This would reduce your chances of suffering a lung cancer even if you happen to be a victim to mesothelioma already.

If a form of cancer stemming from asbestos exposure is primarily non cancerous by nature, the chances of it becoming malignant, increases with the increase in exposure. And this ratio is lesser in cases of mesothelioma where even slight exposure can worsen the situation for the victim. However cigarettes have no contribution to mesothelioma unless of course the immunity level of the patient is incredibly low and the reaction can be instigated.

Also asbestos is not only in the atmosphere where it is predominantly used, asbestos also is in the air around us but these levels are considerably tolerable by the body and do not harm the system unlike the major quantities which are usually inhaled at construction places and the like. It is not necessary that all present around a place where too much asbestos is available will succumb to mesothelioma but there are times it happens to one and not another and that is unfortunate. The reasons for such weird occurences have not been explored yet.

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