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Some Important Symptoms of Mesothelium to Take Precautions

Some Important Symptoms of Mesothelium to Take Precautions

Mesothelioma, a type of cancer of the mesothelium is found around or on lung. It is also called asbestos cancer which is a critical disease. The symptoms of Mesothelium are almost same as lung cancer. This disease can affect the abdomen, lining of the lungs, heart, testicles and also spread to the surrounding tissues. Most of the people who have been exposed to asbestos may get affected by this disease. Various types of mesothelioma are there which make the diagnosis of it very tough. If you see any mesothlioma symptom in you or your loved one then go to a good physician as soon as possible.

One of the most common <a rel=”nofollow” onclick=”javascript:_gaq.push(['_trackPageview', '/outgoing/article_exit_link']);” href=”http://www.ofmesothelioma.com/”>Symptoms of Mesothelioma</a> is the pain in the abdomen and chest. This cancer can create pain in many body parts. The pain gets increased with the development of the cancer. Pleural mesothelioma causes pain in the chest most of the time. The patients can also get problems while breathing. The shortness of breath will increase with the development of this cancer. Pleural effusion is the ultimate result a patient can have because of this. Persistent abdominal pain is another symptom the patient of mesothelioma can have. You should allow this cancer to be developed.

Dry cough and persistent are symptoms of Mesothlioma that can be experienced by many patients. When the cancer will develop into your body you can see blood coming out with your blood. If you see any of these go to a doctor immediately. Most of the people nowadays are going for losing their body weight. But remember that unexplained or large weight loss can be sign of trouble. This sudden and extreme weight loss can be caused by the huge pressure provided by cancerous cells. So, if you have this problem then go and do some test whether everything is all right or not.

Fatigue is a common bodily response to psychological and physical exhaustion. But if you feel fatigued all the time without any reason then it is not normal. This may be one of the symptoms of Mesothelioma also. if you are sweating even after a complete sleep o eight or nine hours then do not late to go to your doctor. With the development of mesotheliomanumbers of cancerous cells grows and interfere in the physiological function. That is why the internal tissues begin to swell and produce night sweats which may also be accompanied by low-grade fever.

Apart from these major <a rel=”nofollow” onclick=”javascript:_gaq.push(['_trackPageview', '/outgoing/article_exit_link']);” href=”http://www.ofmesothelioma.com/”>Symptoms of Mesothelioma</a> some minor symptoms can also be seen.  Blood clotting abnormalities can only be seen in case of mesothlioma. Problem of trouble swallowing can be occurred because of this disease. Anemia is a well-known disease which may be the result of affecting by mesothelioma. If you see all the symptoms altogether in your body then there will be no confusion that you are affected by Mesothelioma. You should go to a doctor and mention the Symptoms of Mesothelioma you have. The doctor may recommend some aggressive therapies which can stop the quick spread of cancer in your body.

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Mesothelioma Prognosis-Why Do Some Patients Survive Longer?

Mesothelioma Prognosis-Why Do Some Patients Survive Longer?

There have been some few patients who have survived far beyond the usual one year prognosis for most mesothelioma victims and a handful that have even been cured, with no trace of the aggressive cancer several years after treatment (though recurrence is always possible).

There seems to be one common factor amongst those that have survived the disease for longer times -a boosted immune system. Studies of those who have either survived or been cured of the disease reveal that most of these patients participated in some sort of therapy that enhanced their immune system. Some treatments included clinical trials in immunology while others involved alternative therapies dealing with the immune system.

A number of mesothelioma survivors have posted their stories on the Internet and have spoken to patients and their families with the hope of providing a brighter outlook for their future. These same survivors have also presented their cases to doctors and researchers. The most outspoken of these individuals is Paul Kraus, an Australian mesothelioma survivor. Kraus was diagnosed with abdominal/ peritoneal mesothelioma in 1997, a form of the disease that is tougher to treat than the more common pleural mesothelioma. Kraus worked in a factory 35 years earlier where he was exposed him to blue (crocidolite) asbestos.

Upon his diagnosis, Kraus changed his diet (he’s now a vegetarian), added many vitamins and supplements to his daily routine, began “juicing,” and tried a treatment known as ozone therapy. Kraus explains, “They took blood out of a vein, used an ozone machine to add ozone (a molecule composed of three oxygen atoms) to the blood and reintroduced it into my body through a drip. The rationale for that was that cancer does not like an oxygenated environment.” The research in putting the protocol together took a lot of time, but in the long-run, Kraus believes the combination of all these treatments stabilized his mesothelioma. Today, tests show he still has the disease and his body is a bit weaker than it was, but he has no pain and his doctors tell him he has many more years to live. Kraus stresses the fact that he is not the only mesothelioma survivor.

He has cited the case of a man diagnosed 14 years ago at age 58 (no name given) who had a chest wall resection after diagnosis and has had no symptoms or recurrence since. His doctors believe there was  that spontaneous regression  he experienced may be an immune-mediated phenomenon, that is  his immune system played a role in his survival.

Another survivor, Rhio O’Connor – who recently published a book about his fight with mesothelioma – has lived with the disease for seven years. He opted against the conventional methods of treatment like surgery, chemotherapy and radiotherapy. Instead, with the help of several medical physicians, he developed a regimen that included 100 supplements per day, changed his diet drastically, and now practices what he calls “mind-body medicine” (such as non-stress techniques like meditation). In his book, he recommends a variety of alternatives to traditional medicines and treatments.

All mesothelioma patients should be encouraged to participate in clinical trials especially those that are trying out new methods of boosting the immune system.

Bello Kamorudeen.For more information on mesothelioma treatments and clinical trials go to http://www.mesotheliomacorner.blogspot.com


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Some Cures For Mesothelioma, Mesothelioma Research And Present Prognosis

Some Cures For Mesothelioma, Mesothelioma Research And Present Prognosis

Mesothelioma is a man made cancer, caused by asbestos which is a naturally found silicate mineral. Asbestos is put to use widely in industries for cement manufacture, construction activities, ship building etc. It is found in mines and its requirement has increased greatly due to its qualities like resistance to heat, insulation capacity etc. But it has not been revealed for many years that the minute particles can cause the deadly form of cancer. Now it is proved beyond doubt, but many have fallen victims to the malicious disease. Hence a mesothelioma prognosis becomes totally shattering and useless in the present scenario.

The cures of mesothelioma, mesothelioma prognosis and researches are topics to be dealt with in detail. The tiny asbestos particles which are inhaled, damage the mesothelium which is the protective covering of our internal organs. The infection gradually spreads and disrupts the normal functioning of the organs. Since there is no complete cure available for the disease, the prognosis of the disease is not advantageous. But there is a ray of hope prevailing that the researches going on at the different laboratories will help to find a proper cure for the disease in the near future.

There are many treatment methods adopted by the doctors which include conventional therapies like radiation and chemotherapy. However these methods have not given hundred percent results since the disease shows up very late. Immediately after the diagnosis, the condition of the patient deteriorates. In case the disease is detected and treated early, there are better chances for survival. But the very characteristics of the disease make it impossible.

Now more emphasis is given to prevention of the cancer due to the cited reasons. The immunity of the workers have to be improved and other practical measures are to be followed to avoid the deadly cancer. Masks and protective clothing are widely used in the workshops and asbestos mines. New therapies like photodynamic therapy, gene therapy, immunotherapy etc are developed by researchers to defeat the cancerous particles.

The joined efforts of various groups interested in the subject will help to overcome the disease. Though cures of mesothelioma, mesothelioma prognosis and prevention tactics are not fully developed now, vast improvements can be expected in the near future.

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Asbsestos Related Diseases Non-Gynaecological Cancers and Some Benign Diseases

Asbsestos Related Diseases Non-Gynaecological Cancers and Some Benign Diseases

Tumor Biology – Vol. 17, No. 1, 1996  by Assoc. Prof. Halis Simsek, MD, Section of Gastroenterology, Hacettepe University Medical School, Resat Nuri sokak No: 21/13, Yukariayranci, Ankara, 06100 (Turkey).  Here is an excerpt: “Abstract – Elevated levels of CA 125 have been shown to be present in the serum of patients with ovarian carcinoma, non-gynaecological cancers and some benign diseases. However, the value of CA 125 in malignant peritoneal mesothelioma has not been studied in detail. Therefore, 7 patients with diffuse malignant mesothelioma were included in this study. Median age was 52.4 (range 16-73), and 6 of them were women. The mean serum CA 125 level was 308kU/l (range 8-1,300 kU/1). Serum CA 125 concentrations were found to be elevated in all 6 female patients. In 3 patients, serum CA 125 levels were followed prospectively and showed a very close correlation with the response to chemotherapy. In 2 responder patients, initially elevated CA 125 levels returned to normal during remission after chemotherapy. In 1 non-responder patient, the serum CA 125 level continued to rise. In conclusion, the serum CA 125 level might be helpful in the diagnosis and follow-up of malignant peritoneal mesothelioma.”

Another interesting study is called, “High-performance capillary electrophoretic analysis of hyaluronan in effusions from human malignant Mesothelioma” – Journal of Chromatography B: Biomedical Sciences and Applications – Volume 697, Issues 1-2, 12 September 1997, Pages 277-281 by Nikos K. Karamanosa and Anders Hjerpeb – Here is an excerpt: “Abstract – A procedure to quantify hyaluronan in effusions from human malignant mesothelioma using a highly sensitive and reproducible high-performance capillary electrophoresis (HPCE) method is presented. Following ethanol precipitation, hyaluronan and galactosaminoglycans were degraded to Δ4.5-dissacharides with a mixture of chondroitinases ABC and AC. Heparan sulphate and proteins/glycoproteins were separated by ultrafiltration on a Centricon 3 membrane, and hyaluronan-derived disaccharides were analysed by direct injection of the filtrate into a HPCE system. Determination of hyaluronan in effusions from five healthy individuals and three patients with mesothelioma gave values comparable to those found using the HPLC method. One of the advantages of the HPCE method as compared to HPLC is the low solvent consumption. The much lower detection limit (attomole level) of the HPCE method may also allow the analysis of hyaluronan content in serum. The contribution of HPCE in diagnosis of a neoplasm, such as human malignant mesothelioma, illustrates the great potential of this technique in the field of life sciences.”

Another interesting study is called, “Protein expression of the RB-related gene family and SV40 large T antigen in mesothelioma and lung cancer” – Nature Publishing Group, Basingstoke, ROYAUME-UNI  (1987) (Revue).  Here is an excerpt: “Abstract – Mutational inactivation of the RB-related gene RBL2/ p130 has been reported as a common and important prognostic factor in human lung cancer. To examine the role of the RB-related gene family in lung cancer we analysed the protein expression of the RB gene in cell lines obtained from 83 patients with small cell lung cancer (SCLC) and 114 patients with non-SCLC that included 21 novel lung tumor samples. While we detected five new SCLC with mutant RB [removed]RB inactivation in 75/83; 90.4%), we did not detect any RB mutations in the new non-SCLC cell lines (RB inactivation in 13/114 non-SCLC and mesothelioma; 11.4%). In addition, we detected expression of a full-length RBL1/p107 and RBL2/p130 species in every sample tested (RBL1 or RBL2 inactivation in 0/69) and confirmed that both RB-related gene products retain functional binding activity to the E1A viral oncoprotein. Since expression of SV40 Large T antigen (Tag) has been reported in a subset of human lung tumors where it may inactivate RBL1 and RBL2, we also examined mesothelioma and non-mesothelioma lung tumors for Tag expression. Although we detected a faint 85 kDa protein species using specific anti-Tag antibodies, this signal migrated slightly faster than Tag extracted from Cos7 cells and did not exhibit binding activity to the RB or RBL1 proteins. Finally, we subjected 11 lung cancer cell lines to nucleotide sequencing and did not detect mutations within the C-terminal RBL2 exons 19-22 as recently reported. While the RB/p16 tumor suppressor pathway is targeted for mutations in 100% of lung cancers, mutational inactivation of the related RBL1 and RBL2 genes is a rare event.”

Another interesting study is called, “Benign cystic mesothelioma involving the female genital tract: report of four cases” by Schneider V, Partridge JR, Gutierrez F, Hurt WG, Maizels MS, Demay RM. – Am J Obstet Gynecol. 1983 Feb 1;145(3):355-9.  Here is an excerpt: “Abstract – Four cases of benign cystic mesothelioma are described. The disease affects young white women (mean age, 30 years), and they present with chronic pelvic pain. At laparoscopy or laparotomy, multiple cysts ranging in size from 0.5 to 4 cm in diameter and containing clear fluid are seen. The disease commonly affects the pelvic organs and/or omentum. With the electron microscope, the cell of origin of this proliferative process is shown to be the mesothelial cell. The disease has been previously described under a variety of terms. There seems to be a tendency for recurrence, but no malignant potential is apparent. Treatment may be conservative with preservation of pelvic organs. Benign cystic mesothelioma should be considered in the differential diagnosis of cystic lesions of the female genital tract.”

Another interesting study is called, “Monoclonal antibody Ber-EP4: Its use in the differential diagnosis of malignant mesothelioma and carcinoma in cell blocks of malignant effusions and FNA specimens” by Dr. Brigid Maguire M.B.B.S., Darrel Whitaker Ph.D., C.F.I.A.C., F.I.M.L.S., A.A.I.M.S., Salvatore Carrello B.App.Sc., Dominic Spagnolo M.B.B.S., F.R.C.P.A. – Diagnostic Cytopathology – Volume 10, Issue 2, pages 130–134, March 1994.  Here is an excerpt: “Abstract – Formal sublimate-fixed cell blocks derived from 129 malignant pleural (and some peritoneal) effusions, 8 benign effusions with reactive mesothelial cells, and 23 FNA specimens, were immunostained with monoclonal antibody Ber-EP4 to assess its ability to distinguish malignant mesothelioma (MM) from carcinoma.

Only 2 of 44 (4%) well-characterized MM were Ber-EP4+, while none of 8 benign mesothelial proliferations reacted with the antibody. Fifty-seven percent of 23 pulmonary adenocarcinomas (AC) and 60% of 43 pulmonary carcinomas of all other histological types were Ber-EP4+. Of 40 metastatic AC originating from breast, gastrointestinal tract, ovary, endometrium, and kidney, 80% were Ber-EP4+. The predictive value of positive Ber-EP4 staining in distinguishing AC from MM was 96%. The predictive value of a negative Ber-EP4 in excluding MM was 70%, when the differential diagnosis was adenocarcinoma. These results suggest that Ber-EP4 is helpful in differentiating MM and AC if used together with other discriminating antibodies.”

We all owe a debt of gratitude to these fine researchers.  If you found any of these excerpts interesting, please read the studies in their entirety.

Monty Wrobleski is the author of this article.  For more information please click on the following links

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