Posts Tagged ‘Study’

Survival May Depend on Race, Study Finds

Survival May Depend on Race, Study Finds

Copyright (c) 2009 Katie Kelley

Researchers have found that disparities may exist between the survival of lung cancer patients between various races, particularly among African Americans who are at a greater risk of fatality following a lung cancer diagnosis compared to those of other races, according to a report from the University of Washington, Seattle researchers.

The study used informational data from 17,739 patients that were of the average age of 75 years old. The data was collected during the time period of 1992 to 2002. Of the patients, approximately 89 percent were of the Caucasian race while only 6 percent were African Americans. According to the research, “black patients recommended to surgery had lung resections less frequently than white patients.”

The report found that as long as African American patients received “recommended appropriate treatment” the disparities shrank considerably, however, that has not been the case thus far, according to a Science Daily news article. Scientists were only able to speculate as to why the disparities occurred between the two races, but reasoned the following differences may be occurring:

* patients may be less inclined to undergo surgery

* patients may be have limited access to appropriate care

* patients may be less likely to visit the physician

However, if these patients had received a proper adjustment or treatment, then “no significant association between race and death” would have occurred, according to the news article.

Lung Cancer Causes

While the Oncology Channel notes that tobacco smoke is responsible for “80 percent of lung cancer deaths in men and 75 percent of lung cancer deaths in women,” there are a significant number of other risk factors that can lead to an individual’s diagnosis of lung cancer. Several risks commonly associated with this include the following:

* secondhand smoke

* asbestos

* radon

* occupational exposures

* age

* race

* sex

* hereditary

It is imperative that in order for a lung cancer patient to receive the best appropriate method of treatment that he/she contact a medical professional at the first signs and symptoms of their potential condition. The following are reoccurring signs and symptoms among lung cancer victims, according to the Mayo Clinic:

* hoarseness

* wheezing

* chest pain

* coughing up blood

* development of chronic cough, also smoker’s cough

* new cough that does not go away

Defining Mesothelioma

Mesothelioma is a deadly form of lung cancer that is caused after the inhalation of asbestos fibers and dust particles has occurred. The New Zealand National Occupational Health and Safety Advisory Committee reported that individuals working in the construction industry, or a similar field, are at the most risk for developing mesothelioma cancer:

* asbestos workers

* auto mechanics

* miners

* millers

* machinery fitters

* boilermakers

* firemen

* waterside workers

* railway workers

* construction workers

Individuals who have worked in any of the above fields or a similar work environment are advised to seek medical attention if any of the above signs and symptoms develop. Additionally, it is important that an individuals suffering from mesothelioma cancer contact an environmental toxin attorney to learn about developing a mesothelioma lawsuit.

It is often necessary to create such litigation as a mesothelioma diagnosis is frequently delivered with expensive treatment options and a short life expectancy. By creating a mesothelioma lawsuit an individual is increasing their chance of receiving monetary compensation as an award for their debilitating condition.

Individuals can obtain more information on the mesothelioma risks by visiting http://mesothelioma.legalview.com or http://www.LegalView.info/. Here, readers can locate the latest on the peanut butter recall as well as how to garner legal advice from an automobile accident attorney.


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Scientists Unveil Research Study Pointing Toward Mesothelioma Cancer Treatment

Scientists Unveil Research Study Pointing Toward Mesothelioma Cancer Treatment

When nonseroidal anti-inflammatory drugs (NSAIDs), such as aspirin, are combined with Piroxicam and cisplatin (CDDP) they produce an anti-tumoral treatment of cancerous cells, specifically malignant mesothelioma cancer cells. These results, published in May 2008 in the Journal of Translational Medicine, are getting plenty of attention by both scientists as well as victims of mesothelioma cancer. Prior to this study, the prognosis for malignant mesothelioma cancer was grim, even at best, but now, researchers are breaking open a can of worms that may provide treatment for the deadly cancer caused by the inhalation of asbestos dust.

While this study offers a slice of hope for victims, the further research is required. Scientists with this study also found that the potential for determining a specific molecular target of mesothelioma cells, because of these drugs’ anti-tumor effects, could lead to advances in therapy treatments of the deadly cancer.

What is Malignant Mesothelioma Cancer?

There are several varieties of mesothelioma cancer, however, malignant mesothelioma is considered one of the most lethal. According to the study, “prognosis is poor and patients have a median survival of a few months in either treated or untreated cases.” Malignant mesothelioma is a rare cancer with malignant cancer cells forming on the sac lining of the chest or abdomen, according to the National Cancer Institute (NCI). It is often associated with exposure to airborne asbestos particles and fibers, which increases the risk of malignant mesothelioma developing in an individual.

Signs and Symptoms of Malignant Mesothelioma

Malignant mesothelioma is often marked by several symptoms including lumps in abdomen, weight loss, pain or swelling in the abdomen, pain under the rib cage and difficulties breathing. The cancer can also often cause fluid retention in the abdomen or around the lungs. The cancer often has symptoms similar to other conditions making misdiagnosis of the condition common.

Medical professionals have even admitted that malignant mesothelioma and lung cancer are very similar and differentiating between the two is difficult, however, there is an array of tests that physicians can use to increase the potential for a more accurate diagnosis. Tests for diagnosis may include the patient enduring physical exams, chest x-rays, biopsy of body tissues, getting a complete blood count (CBC), cytologic exam, which is an exam of cells under a microscope, or a bronchoscopy procedure where a bronchoscope is inserted into the nose or mouth for a better view of airways.

Diagnosing and Treating Malignant Mesothelioma

While treatments for mesothelioma are rare in and of themselves, it becomes increasingly difficult to treat malignant mesothelioma because of the severity of the condition. However, medical professionals take into consideration several factors prior to treatment to determine a patient’s prognosis. The following is a detailed list of these factors, according to the NCI:

* The stage of cancer, which includes stage I or localized malignant mesothelioma or advanced malignant mesothelioma that includes stage II, stage III and stage IV.

* The size of a tumor.

* Potential for tumor removal through a surgical procedure.

* The amount of fluid gathered in the chest or abdomen.

* A victim’s age, physical health and previous health issues.

* Type of mesothelioma cancer.

* Whether a cancer is diagnosed as reoccurring or not.

Often, cancer may spread through the lymph system, blood stream or other bodily tissues.

Treatments for malignant mesothelioma can range from surgery to therapy, including chemotherapy and biological therapy to clinical trials, although the outcome is based on the progression of the cancer and most often, individuals are not aware of their condition until it reaches an advanced and, usually, an untreatable stage.

Asbestos Exposure and What to Do

Asbestos is a mineral fiber that was used heavily in a range of building materials from vinyl flooring to insulation. It was prized for its inexpensive production costs and fire-retardant ability making it ideal among construction companies. Unfortunately, the inhalation of high levels of asbestos dust and fibers contributed to the development of mesothelioma cancer.

Unfortunately, this discovery came far too late, as millions of Americans working in the industry were exposed and millions more continue to remain at risk for exposure as asbestos still exists in homes, schools, apartment complexes and dozens of other types of buildings across the country. Individuals who believe they may have been exposed to asbestos particles and fibers should seek medical attention as soon as possible. If mesothelioma is the outcome it is advisable for a patient to receive consultation from an experienced mesothelioma attorney, as the potential for a mesothelioma lawsuit may exist with the opportunity for monetary compensation.

For more information on mesothelioma treatments, visit http://mesothelioma.legalview.com/. Here, users can find the latest jury verdicts and news. Also use the LegalView homepage at http://www.LegalView.com/ and learn about legal issues ranging from the Digitek Digoxin side effects to Levaquin risks.


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Malignant Pleural Mesothelioma Evaluated in a Randomized Study

Malignant Pleural Mesothelioma Evaluated in a Randomized Study

Another interesting study is called, “Randomized trial of doxorubicin versus cyclophosphamide in diffuse malignant pleural Mesothelioma” by Sørensen PG, Bach F, Bork E, Hansen HH – Cancer Treat Rep. 1985 Dec;69(12):1431-2.  Here is an excerpt: “Abstract – The effect of doxorubicin and cyclophosphamide in the treatment of diffuse, malignant pleural mesothelioma was evaluated in a randomized study. All patients were treated on an outpatient basis and none had previously received antineoplastic treatment. All patients had a measurable lesion other than pleural effusion. The treatment consisted of doxorubicin at a dose of 60 mg/m2 every 3 weeks, to a total dose of 550 mg/m2, or cyclophosphamide at a dose of 1500 mg/m2 every 3 weeks for 1 year. At disease progression the treatment was changed to the alternate drug. The dose was increased or decreased according to hematologic effects. Thirty of 32 patients were evaluable for response. Remissions were not achieved in any patient. During treatment with doxorubicin, none of the patients developed cardiotoxicity, while one patient developed hemorrhagic cystitis during treatment with cyclophosphamide. Sepsis or bleeding was not observed in either of the treatment arms. Thus, the trial showed no antineoplastic activity of either doxorubicin or cyclophosphamide in the treatment of malignant pleural mesothelioma.”

Another interesting study is called, “Gene therapy using adenovirus carrying the herpes simplex-thymidine kinase gene to treat in vivo models of human malignant mesothelioma and lung cancer.” By Hwang HC, Smythe WR, Elshami AA, Kucharczuk JC, Amin KM, Williams JP, Litzky LA, Kaiser LR, Albelda SM – Department of Medicine; University of Pennsylvania Medical Center, Philadelphia – Am J Respir Cell Mol Biol. 1995 Jul;13(1):7-16.  Here is an excerpt: “Abstract – Previous studies have shown adenoviral transfer of the herpes simplex virus thymidine kinase (HSVtk) gene followed by the anti-viral drug ganciclovir (GCV) can be used to successfully treat established human mesothelioma tumors growing within the peritoneal cavities of severe combined immune deficient (SCID) mice. These findings raised a number of questions important to the applicability, efficiency, and safety of this treatment strategy. In this report, we have further characterized the use of recombinant adenovirus carrying the HSVtk gene to treat mesothelioma and other localized malignancies. Our results indicate that the Ad.RSVtk/GCV system is effective in causing tumor regression in animals inoculated with another mesothelioma cell line and a lung cancer cell line and that animals with bulky disease can be successfully treated. Effects are seen at a wide range of virus doses and significant anti-tumor activity is present at doses of ganciclovir that are clinically achievable. Finally, this treatment approach appears safe, with limited dissemination of virus using a sensitive RT-PCR detection system. These studies further characterize the use of adenoviral transfer of the HSVtk gene to treat experimental mesothelioma and suggest that clinical trials using this approach may be feasible.

Another interesting study is called, “The diagnostic utility of immunohistochemistry in distinguishing between mesothelioma and renal cell carcinoma: A comparative study
Human pathology” by ORDONEZ Nelson G. – 2004, vol. 35, no6, pp. 697-710 [14 page(s) (article)] (92 ref.)  Here is an excerpt: “Abstract – Both mesotheliomas and renal cell carcinomas can present a wide variety of morphological patterns. Because of this, renal cell carcinomas that metastasize to the pleura and lung may be confused with mesotheliomas. The aim of the present study was to compare the value of the various immunohistochemical markers currently available for the diagnosis of mesothelioma and renal cell carcinoma. A total of 48 mesotheliomas (40 epithelioid, 8 sarcomatoid), and 48 renal cell carcinomas (24 conventional, 12 chromophobe, 8 papillary, 4 sarcomatoid) were investigated for the expression of the following markers: calretinin, mesothelin, cytokeratin 5/6, WT1, thrombomodulin (TM), N-cadherin, CD15 (leu-M1), MOC-31, Ber-EP4, BG-8 (Lewisy), CD10, renal cell carcinoma marker (RCC Ma), carcinoembryonic antigen (CEA), and B72.3. All (100%) of the epithelioid mesotheliomas reacted for calretinin, mesothelin, and cytokeratin 5/6; 93% for WT1; 78% for TM; 75% for N-cadherin, 48% for CD10, 15% for Ber-EP4,8% for MOC-31, 8% for RCC Ma, 5% for BG-8, and none for CEA, B72.3, or CD15. Of the sarcomatoid mesotheliomas, 88% expressed calretinin, 75% N-cadherin, 38% CD10, and 13% each expressed cytokeratin 5/6, WT1, and TM. All of the remaining markers were negative. Among the RCCs, 81% expressed CD10, 75% N-cadherin, 63% CD15, 50% RCC Ma, 50% MOC-31, 42% Ber-EP4, 8% BG-8, and 2% TM. The remaining markers were negative. The results indicate that calretinin, mesothelin, and cytokeratin 5/6 are the best positive mesothelioma markers for differentiating epithelioid mesotheliomas from renal cell carcinomas. The best discriminators among the antibodies considered negative markers for mesothelioma are CD15, MOC-31, and RCC Ma. An accurate differential diagnosis can be reached with the use of any 2 of the 3 recommended positive markers, which should be selected based on availability and on which ones yield the best staining results in a given laboratory. One of the recommended negative markers may be added to the panel if deemed necessary. If confirmation of renal origin is needed, RCC Ma could be useful. Calretinin is the only marker that appears to have any utility in distinguishing between sarcomatoid mesotheliomas and sarcomatoid renal cell carcinomas.”

We all owe a debt of gratitude to these fine researchers.  If you found any of these excerpts interesting, please read the studies in their entirety.

Monty Wrobleski is the author of this article.  For more information please click on the following links

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New Drug Study for Abdominal Mesothelioma

New Drug Study for Abdominal Mesothelioma

Researchers recently published the results of a study in the Journal of Clinical Oncology detailing a potentially new treatment for patients of abdominal mesothelioma that will likely improve the condition for patients.


The study found that when patients suffering from abdominal mesothelioma were given a combination of two drugs, Alimta (pemetrexed) and Gemzar (gemcitabine), their condition improved. The following are the results of the study:


* Response rate among patients was 15 percent.


* The control rate of the disease for patients while on the medication was 50 percent.


* The median time to disease progression was 10.4 months.


* The median survival time was 26.8 months.


* The mesothelioma study involved 20 patients suffering from the condition.


Each patient also received various vitamins including folic acid, vitamin B12 and dexamethasone. The study was conducted by researchers involved in a multi-center U.S. trial. Researchers expect to continue studying the drug’s effects on abdominal mesothelioma patients to determine if the treatment can be improved.


What is Abdominal Mesothelioma?


Abdominal mesothelioma is an extremely rare form of mesothelioma cancer. Commonly described as peritoneal mesothelioma, the cancer affects the abdominal lining, which is also known as the peritoneum. Within the abdominal cavity is the serous membrane, which is also known as the parietal peritoneum, and this membrane continues on to the visceral peritoneum that lines the organs. With abdominal mesothelioma, the visceral and parietal peritoneum linings are affected with the development of cancerous cells.


Most often, abdominal cancer occurs when an individual first develops pleural mesothelioma, which is when the lining of the lung develops cancerous cells after inhalation of asbestos. Pleural mesothelioma can then spread to the peritoneal cavity and cause peritoneal mesothelioma, which accounts for less than one-third of all mesothelioma diagnoses.


How is Peritoneal Mesothelioma Contracted?


Abdominal, or peritoneal, mesothelioma is caused through the inhalation of asbestos fibers or asbestos dust. Asbestos is a material that is derived from vermiculite, a mineral that was mined heavily in the United States and around the world in the 20th century. Asbestos was most commonly used as an insulation within the construction industry because it was flame resistant and was developed at inexpensive prices.


There are many common symptoms of mesothelioma, including:


* shortness of breath.


* inability to breath.


* fatigue.


* wheezing or severe cough.


However, many of these symptoms are generalized to overall cases of mesothelioma. Specific symptoms exist for those diagnosed with peritoneal mesothelioma. These symptoms are as follows:


* weight loss.


* abdominal swelling, which can be caused by ascites or the buildup of fluid in the abdominal cavity.


* bowel obstruction.


* fever.


* anemia.


* blood clotting.


* trouble swallowing.


* swelling of neck and face.


Abdominal Mesothelioma Treatment


Abdominal mesothelioma treatments commonly consist of surgical procedures to remove the infected cancerous areas. Often, the main surgery involved with peritoneal mesothelioma is known as cytoreductive surgery. This surgery is usually accompanied with perioperative intraperitoneal chemotherapy, and together the median survival rate for patients has been shown to increase slightly, although, treatment is dependent on a specific case-by-case basis.


Obtaining Peritoneal Mesothelioma Legal Help


Individuals who have been diagnosed with peritoneal mesothelioma or any similar form of mesothelioma cancer are advised to locate an experienced mesothelioma attorney. Because mesothelioma is considered a highly preventable disease, individual victims who contract the illness were likely exposed to asbestos fibers or asbestos dust without knowledge of the danger of exposure levels. These individuals may be able to receive monetary compensation for the extremely costly medical bills associated with abdominal mesothelioma.


It is especially important for an individual to seek legal counsel for their mesothelioma lawsuit if they were an employee within the metal, mining, maritime, construction and welding industries.

Learn more about abdominal mesothelioma and treatments at http://mesothelioma.legalview.com or visit http://www.LegalView.com/ . Additionally, LegalView offers information on other various legal issues such as the Cipro risks or the latest on truck accident lawsuits.


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Has someone you know been diagnosed with Peritoneal Abdominal Mesothelioma? Find out what you need to know about Mesothelioma at our website kazanvideo.com. Peritoneal Mesothelioma is a rare form of Mesothelioma that effects the Peritoneum, or abdominal lining. If you have been diagnosed with Peritoneal or Abdominal Mesothelioma in the Modesto area, make an informed decision about your legal representation. Call 877.622.5246 today.
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Study Finds Increased Mesothelioma Death Rates In A Group Of Shipyard Workers

Study Finds Increased Mesothelioma Death Rates In A Group Of Shipyard Workers

A recent study conducted on workers in a US Coast Guard shipyard has found a significantly greater mortality rate associated with lung cancer and mesothelioma compared to the general population. The study also found an increased general mortality rate.

The study followed 4702 (4413 men and 289 women) civilian workers who were employed at the shipyard between January 1950 and December 1964. The study then measured the number of deaths and their causes through 31 December 2001.

The study was conducted by S Krstev, P Stewart, J Rusiecki, A Blair and was published in Occupational and Environmental Medicine. The original study publication is available at http://oem.bmj.com/cgi/content/abstract/64/10/651.

Mesothelioma is a form of cancer that is usually associated with exposure to asbestos. The majority of individuals who are diagnosed with mesothelioma have a history of exposure to asbestos particles at work or home. Family members of workers have also been affected. Renovators of homes containing asbestos cement material are accounting for an increasing number of diagnosed sufferers. Symptoms of mesothelioma may not appear for decades after the exposure to asbestos. Symptoms include abdominal pain and weight loss. Diagnosis of mesothelioma can be difficult due to the fact that the symptoms are similar to other respiratory diseases.

Since mesothelioma is primarily caused by exposure to asbestos, mesothelioma can be best be prevented by avoiding or limiting exposure to asbestos in homes, public buildings, and at work. Workers that may be at risk include miners, factory workers, insulation manufacturers, railroad workers, ship builders, contractors and construction workers, particularly those involved with insulation. If there is a possibility of exposure (such as when renovating old buildings) protective equipment should be used and safety procedures should be applied. Asbestos was commonly used in building materials due to its durability and fire-resistant properties. In addition to buildings, asbestos was used in the manufacture of cars and ships and many other products.

Sam Gurgis is a scientific writer and the webmaster at mesotheliomawise.org and sam-gurgis.com


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